ArticleInternational journal of clinical and experimental medicine2015
Correlation of polymorphism of APOE and LRP genes to cognitive impairment and behavioral and psychological symptoms of dementia in Alzheimer's disease and vascular dementia.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial.Alzheimer's research & therapy · 2020Trial
- Relationship betweenInternational journal of environmental research and public health · 2023Article
- Behavioral Disturbances in Dementia and Beyond: Time for a New Conceptual Frame?International journal of molecular sciences · 2019Review
- Absolute 10-year risk of dementia by age, sex andCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo discuss the correlation of polymorphism of APOE and LRP genes to cognitive impairment and behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and vascular dementia (VD).
methodAD cases, VD cases and healthy control cases totaling 237, 255 and 234 were recruited, respectively. The mini-mental state examination (MMSE) was performed to evaluate cognitive impairment. Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were adopted to evaluate BPSD. Apolipoprotein E (APOE) and Low-density lipoprotein receptor-related protein gene (LRP) genotyping was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
results(1) Frequencies of APOEε4 allele in AD group and VD group were significantly higher than that of the control (P<0.05); (2) MMSE scores of APOEε4 carriers in AD group and VD group were lower than that of non-APOEε4 carriers in the same group (P<0.05); (3) The proportion of APOEε4 carriers presenting with BPSD in AD group was considerably higher that of non-APOEε4 carriers (P<0.05).
conclusionAPOEε4 may be the common risk factor for cognitive impairment in AD and VD and the risk factor for BPSD in AD.
Indexed as
Identifiers
26885125PMC4723970W2289507061What OpenQuestion holds
Registered trials
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