ArticleInternational journal of clinical and experimental medicine2015
Association of genetic polymorphisms in PTEN and additional interaction with alcohol consumption and smoking on colorectal cancer in Chinese population.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Four novel polymorphisms in long non-coding RNA HOTTIP are associated with the risk and prognosis of colorectal cancer.Bioscience reports · 2019Article
- Effects of interactions between common genetic variants and alcohol consumption on colorectal cancer risk.Oncotarget · 2018Article
- Effects of interactions between common genetic variants and smoking on colorectal cancer.BMC cancer · 2017Article
- Single nucleotide polymorphisms rs701848 and rs2735343 in PTEN increases cancer risks in an Asian population.Oncotarget · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate the association of phosphatase and tensin homologue deleted on chromosome ten (PTEN) gene rs3830675, and additional interaction with drinking and smoking on colorectal cancer (CRC), based on a hospital based Chinese case-control study.
methodsA total of 850 subjects (413 males and 437 females) were studied, including 422 colorectal cancer cases and 428 controls. Rs3830675 was selected for genotyping in the case-control study. Logistic regression model was used to examine the association between rs3830675 and colorectal cancer, and additional interaction with alcohol consumption and smoking.
resultsThe frequencies for rs3830675 (-) alleles was higher in cases than that in controls, (-) allele of rs3830675 was 24.4% in controls and 29.4% in CRC subjects (p=0.005). Logistic analysis showed that the carriers of (-) allele of rs3830675 revealed increased CRC risk than those with (+/+) genotype, adjusted OR (95% CI) was 1.35(1.12-1.98). We found a significant interaction between alcohol consumption and rs3830675, drinkers with (-/-) or (-/+) of rs3830675 genotype have highest colorectal cancer risk, compared to never drinking subjects with (+/+) genotype, OR (95% CI) was 2.57 (1.66-3.33), after covariates adjustment. In addition, we also found that smokers with (-/-) or (-/+) of rs3830675 genotype have highest colorectal cancer risk, compared to never smokers with (+/+) genotype, OR (95% CI) was 3.01 (1.58-6.05).
conclusionsThe (-) allele of rs3830675 was positively with colorectal cancer risk. There was a significant role of interaction of rs3830675 with alcohol consumption and smoking on colorectal cancer.
Indexed as
Identifiers
26885116PMC4723961W2466249365What OpenQuestion holds
Registered trials
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