Evidence map›Paper›PMID 26885115›Full record

ArticleInternational journal of clinical and experimental medicine2015

Serum cholesterol levels in middle-aged euthyroid subjects with positive thyroid peroxidase antibodies.

Dongmei Kang, Quhua Yin, Xiaoli Yan, Huaidong Song, Guanqi Gao, Jun Liang, Jiajun Zhao

Abstract read
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In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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  8. Autoimmune Hashimoto's Disease and Feminization Level-TestingEvolutionary psychology : an international journal of evolutionary approaches to psychology and behavior
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dongmei KangDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021, Shandong, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical MedicineJinan 250021, Shandong, China; Department of Geriatrics, Anhui Provincial Hospital Affiliated to Anhui Medical UniversityHefei 230001, Anhui, China.
Quhua YinDepartment of Geriatrics, Anhui Provincial Hospital Affiliated to Anhui Medical University Hefei 230001, Anhui, China.
Xiaoli YanDepartment of Geriatrics, Anhui Provincial Hospital Affiliated to Anhui Medical University Hefei 230001, Anhui, China.
Huaidong SongDepartment of Endocrinology, Ruijin Hospital Affiliated to SJTU School of Medicine, State Key Laboratory of Medical Genomics and Shanghai Institute of Endocrinology and Metabolism Shanghai 200025, China.
Guanqi GaoDepartment of Endocrinology, The People's Hospital of Linyi Linyi 276003, Shandong, China.
Jun LiangDepartment of Endocrinology, The Central Hospital of Xuzhou Affiliated to Xuzhou Medical College Xuzhou 221109, Jiangsu, China.
Jiajun ZhaoDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021, Shandong, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical MedicineJinan 250021, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was designed to investigate serum cholesterol levels in middle-aged euthyroid subjects with positive thyroid peroxidase antibodies (TPOAbs).

methodsWe screened 1607 euthyroid subjects aged 35-65 years old. All the subjects were divided into 2 groups (i.e., TPOAb-positive group, n=205; TPOAb-negative group, n=1402) according to the level of TPOAb. The subjects were then subgrouped according to serum thyroid stimulating hormone (TSH) levels; those with a TSH level of 0.3-0.99 mIU/L, 1.0-1.89 mIU/L, and 1.9-4.80 mIU/L were classified into the low-normal, mid-range, and high-normal TSH subgroups, respectively). Each TSH group further subdivided into TPOAb-positive and TPOAb-negative subgroup. Data regarding the subjects' height, body weight, blood pressure, and levels of serum TSH, TPOAb, fasting plasma glucose, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were collected.

resultsCompared with TPOAb-negative subjects, TPOAb-positive patients had higher levels of TSH, TC, and HDL-C (P=0.001, P=0.012, and P=0.049 respectively) with a tendency for increased LDL-C levels (P=0.053). In the low-normal TSH subgroup, subjects with and without TPOAb had similar levels of TSH, TC, HDL-C, and LDL-C (P>0.05). In mid-range TSH subgroup, TPOAb-positive patients had higher HDL-C levels compared to TPOAb-negative subjects (P=0.008) and a tendency for increased TC levels (P=0.121). In the high-normal TSH subgroup, TPOAb-positive patients had higher TSH and TC levels compared to TPOAb-negative subjects (P<0.001 and P=0.046 respectively).

conclusionsHigh TPOAb levels above the normal range appears in euthyroid population, dyslipidemia have begun.

Indexed as

high density lipoprotein cholesterolThyroid peroxidase antibodythyroid-stimulating hormonetotal cholesterol

Identifiers

PMID26885115
PMCPMC4723960

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.