ArticleInternational journal of clinical and experimental medicine2015
CXCR7 expression in nasopharyngeal carcinoma tissues correlates with disease severity.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Prognostic value of neutrophil-to-lymphocyte ratio for nasopharyngeal carcinoma: A meta-analysis.Medicine · 2017Pooled it
- The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both.Biomarker research · 2021Review
- Highly expressed CCR7 predicts poor prognosis in locally advanced nasopharyngeal carcinoma.Irish journal of medical science · 2020Article
- Role of CXCR7 as a Common Predictor for Prognosis in Solid Tumors: a Meta-Analysis.Journal of Cancer · 2018Article
- Integrative analysis of BSG expression in NPC through immunohistochemistry and public high-throughput gene expression data.American journal of translational research · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chemokine CXCL12 and its receptors, CXCR4 and CXCR7, are important contributors to the pathogenesis of multiple types of tumors. CXCL12/CXCR4 was previously demonstrated to be upregulated in nasopharyngeal carcinoma (NPC) tissues, but the status of CXCR7 in NPC remains unknown. Here, 62 nasopharyngeal carcinoma specimens were obtained from patients who received rhinitis biopsy in our hospital in 2012 and 2013. Another 30 samples were collected from patients with nasopharyngitis who did not have NPC, to serve as a control group. Expression of CXCR7 protein and mRNA in NPC and normal tissues was detected by immunohistochemistry and quantitative real-time polymerase chain reaction, respectively. CXCR7 protein was detected in just 7.1% (2/30) of normal nasopharyngeal samples, but 61.3% (38/62) of tumor tissues (P<0.05). The staining patterns (proportion of stained cells/sample as well as staining intensity) were correlated with lymph node metastasis, TNM staging, and disease severity (P<0.01). Thus, CXCR7 may promote disease progression in nasopharyngeal carcinoma, and may be useful as a predictor of metastasis and prognosis.
Indexed as
Identifiers
26885064PMC4723909W2466331724What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.