ArticleInternational journal of clinical and experimental medicine2015
Expression and clinical significance of Tiam1 gene in esophageal carcinoma.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Fibulin-3 sponges Tiam1 to manipulate MMP-7 activity through β-catenin signaling in oral squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2022Article
- Up-Regulation of Tiam1 Promotes the Radioresistance of Laryngeal Squamous Cell Carcinoma Through Activation of the JNK/ATF-2 Signaling Pathway.OncoTargets and therapy · 2020Article
- Elevated expression of Tiam1 is associated with poor prognosis and promotes tumor progression in pancreatic cancer.OncoTargets and therapy · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship between Tiam1 gene expression and the invasion and metastasis of esophageal cancer.
methodsBy RT-PCR technique, Tiam1 mRNA expression levels in 49 cases of esophageal cancer tissues and normal esophageal tissues were detected.
resultsAverage Tiam1 mRNA expression level in 49 cases of esophageal cancer tissues (1.83 ± 0.73) was significantly higher than that in normal esophageal tissues (0.87 ± 0.45) (P < 0.01); High Tiam1 mRNA expression rate in esophageal cancer tissues was positively correlated with clinical stage and T stage; Tiam1 mRNA expression rate was 59.38% (19/32) in patients with lymph node metastasis, and in patients without lymph node metastasis it was 23.53% (4/17), with statistically significant differences (P < 0.05).
conclusionTiam1 gene expression in esophageal cancer tissues was significantly higher than that in normal esophageal tissues, and its overexpression was positively correlated with invasion and metastasis of esophageal cancer.
Indexed as
Identifiers
26885059PMC4723904W2413164794What OpenQuestion holds
Registered trials
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