ArticleInternational journal of clinical and experimental medicine2015
The independent association of platelet parameters with overall survival in pancreatic adenocarcinoma receiving intensity-modulated radiation therapy.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Prognostic Value and Clinicopathologic Features of Platelet Distribution Width in Cancer: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2018Pooled it
- Evaluation of platelet indices as diagnostic biomarkers for colorectal cancer.Scientific reports · 2018Trial
- Inflammation indices in association with periodontitis and cancer.Periodontology 2000 · 2024Review
- Perioperative Platelet Count Ratio Predicts Long-Term Survival after Left Pancreatectomy and Splenectomy for Pancreatic Adenocarcinoma.Journal of clinical medicine · 2024Article
- Preoperative blood testing for glioblastoma, brain metastases, and primary central nervous system lymphoma differentiation.Translational cancer research · 2022Article
- Article
- The different associations between platelet distribution width and hypertension subtypes in males and females.Bioscience reports · 2020Article
- Preoperative plateletcrit is a Prognostic Biomarker for Survival in Patients with Non-Small Cell Lung Cancer.Journal of Cancer · 2020Article
- Prognostic values of platelet-associated indicators in advanced breast cancer.Translational cancer research · 2019Article
- Prognostic value of mean platelet volume to plateletcrit ratio in patients with osteosarcoma.Cancer management and research · 2019Article
- Prognostic Values of Platelet-Associated Indicators in Resectable Lung Cancers.Technology in cancer research & treatment · 2019Article
- Pretreatment platelet count as a prognostic factor in patients with pancreatic cancer: a systematic review and meta-analysis.OncoTargets and therapy · 2018Article
- The red distribution width and the platelet distribution width as prognostic predictors in gastric cancer.BMC gastroenterology · 2017Article
- Hematological predictors and clinical outcomes in cardiac surgery.Journal of anesthesia · 2016Article
- Prognostic Values of Platelet-Associated Indicators in Resectable Cervical Cancer.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelets are involved in multiple links of the process of thrombus formation and development. The aim of this study is to investigate the impact of pretreatment platelet parameters, such as plateletcrit (PCT), platelet mean distribution width (MDW), and mean platelet volume (MPV) in a cohort of patients with locally advanced pancreatic adenocarcinoma treated with a combination of chemotherapy and radiation therapy.
methodsA retrospective analysis was conducted of 163 locally advanced unresectable consecutive pancreatic adenocarcinoma patients who received chemoradiotherapy in Zhejiang cancer hospital from January 2009 to December 2011. The effects of platelet parameters on overall survival (OS) were assessed using Kaplan-Meier analysis. Independent prognostic factors were identified in the multivariate Cox analysis.
resultsThe median of the PC, PCT, MDW, MPV and CRP were 175×10(9), 20.0%, 14.0%, 10.8 fl and 7.0 mg/L, respectively. MDW was positively correlated with PC (r=0.156, P=0.047) and CRP (r=0.591, P<0.001). The median survival time of high MDW group was significantly worse than that of low MDW group (14.0 m Vs 11.0 m, P=0.008). Patients with high PCT were found to have shorter overall survival time (15.0 m Vs 11.0 m, P=0.018). Multivariate analysis indicated that MDW and N stage were two independent prognostic factors for overall survival (P<0.05). Patients with higher MDW had a 1.48-fold increased risk of death compared to those with low MDW.
conclusionsMDW is an independent negative prognostic factor for overall survival in pancreatic adenocarcinoma patients.
Indexed as
Identifiers
26885057PMC4723902W2287397837What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.