ArticleInternational journal of clinical and experimental medicine2015
Genetic association between hOGG1 C8069G polymorphism and colorectal cancer risk.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Association Between the hOGG1 1245C>G (rs1052133) Polymorphism and Susceptibility to Colorectal Cancer: a Meta-analysis Based on 7010 Cases and 10,674 Controls.Journal of gastrointestinal cancer · 2021Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundhOGG1 C8069G polymorphism has been extensively investigated in single studies as well as meta-analyses in terms of the association with colorectal cancer (CRC). But the results remain contradictory. This study was undertaken to comprehensively evaluate the association of the commonly studied hOGG1 C8069G polymorphism and the susceptibility to CRC.
methodsBy searching the electronic databases of PubMed, Embase, and Web of science, 16 available publications consisting of 4,866 cases and 7,363 controls were finally included in our meta-analysis. Stratified analyses by ethnicity and source of control were also carried out to further assess the association between hOGG1 C8069G polymorphism and CRC risk.
resultshOGG1 C8069G polymorphism was not observed to have statistical significance with the susceptibility to CRC (ORCC vs. GG = 0.97, 95% CI = 0.91-1.05; P = 0.995; ORCC + CG vs. GG = 0.98, 95% CI = 0.93-1.04; P = 0.993; ORCC vs. CG + GG = 0.96, 95% CI = 0.90-1.02; P = 0.339; ORallele C vs. allele G = 0.98, 95% CI = 0.94-1.02; P = 0.912; ORCG vs. GG = 0.95, 95% CI = 0.88-1.03; P = 0.526). Similarly, no association was found in the subgroup analysis by ethnicity or the source of control.
conclusionsThe results of our meta-analysis did not demonstrate any evidence for significant association between hOGG1 C8069G polymorphism and CRC risk. Future large-scale studies are expected to be conducted to further confirm our findings.
Indexed as
Identifiers
26885047PMC4723892What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.