ArticleInternational journal of clinical and experimental medicine2015
Antioxidant and antitumor effects of ferula sinkiangensis K. M. Shen.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
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- The current status of old traditional medicine introduced from Persia to China.Frontiers in pharmacology · 2022Review
- The Inhibitory Effect and Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- The Cao-Xiang-Wei-Kang formula attenuates the progression of experimental colitis by restoring the homeostasis of the microbiome and suppressing inflammation.Frontiers in pharmacology · 2022Article
- Anti-inflammatory, anti-oxidant, and immunomodulatory activities of the genusIranian journal of basic medical sciences · 2021Review
- Carotane sesquiterpenes fromRSC advances · 2020Article
- Cytotoxic activity of the genusAvicenna journal of phytomedicineReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study is to investigate the antioxidant and antitumor effects of the extract fractions of the Ferula sinkiangensis K. M. Shen.
methodsFour different fractions of the Ferula sinkiangensis K. M. Shen were obtained by the extraction with petroleum ether, ethyl acetate, n-butanol, and methanol, respectively, which were used to treat the HCT116, Caco-2, HepG2, and MFC cells. Free radical scavenging effects of the ferula fractions were deteced with the DPPH assay. Effects of the ferula fractions on the peroliferatoin of the tumor cells were assessed with the SRB assay. Apoptosis was detected with flow cytometry.
resultsThe DPPH assay showed that the petroleum ether fraction hardly showed any antioxidant activity, while the ethyl acetate, n-butanol, and methanol fractions exhibited free radical-scavenging capacities, in a dose dependent manner. The SRB assay showed that, the proliferation of the tumor cells could be inhibited by the ferula fractions, in a dose dependent manner. However, differential effects were observed for the different fractions in different model cells. Particularly, the ethyl acetate fraction exerted the most efficient inhibiting effects on the tumor cell proliferation. In addition, the flow cytometry showed that, all the ferula fractions significantly enhanced the apoptotic process in the tumor cells, with differential enhancing capacities in different model cells.
conclusionExtract fractions of the Ferula sinkiangensis K. M. Shen could exert antioxidant, proliferation-inhibiting, and apoptosis-enhancing effects in tumor cells. Particularly, the ethyl acetate fraction exhibits the most potent antioxidant and antitumor effects.
Indexed as
Identifiers
26885009PMC4723854W2276944378What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.