ArticleInternational journal of clinical and experimental medicine2015
Levels of CEA, CA153, CA199, CA724 and AFP in nipple discharge of breast cancer patients.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- CircRNAs as biomarkers of cancer: a meta-analysis.BMC cancer · 2018Pooled it
- CA153 in Breast Secretions as a Potential Molecular Marker for Diagnosing Breast Cancer: A Meta Analysis.PloS one · 2016Pooled it
- New method for cytological evaluation using direct nipple discharge without aspiration.Scientific reports · 2025Article
- Laboratory parameters-based logistic regression models for rapid screening of thyroid nodules.Gland surgery · 2024Article
- Can serum ferritin serve as a biomarker for the prognosis of gynecological malignant tumors? A retrospective cohort study.Cancer biomarkers : section A of Disease markers · 2024Article
- Serum CA724 has no diagnostic value for gastrointestinal tumors.Clinical and experimental medicine · 2023Article
- AFP and CA-125 as an accurate risk factor to predict eye metastasis in hypertension patients with liver carcinoma: A STROBE-compliant article.Frontiers in genetics · 2022Article
- Multiple Metastases of the Liver and Lung After Breast-Conserving Surgery for Ductal CarcinomaFrontiers in oncology · 2022Review
- Primary neuroendocrine carcinoma of the breast with markedly elevated alpha-fetoprotein: a case report.Translational cancer research · 2021Article
- Plasma circRNAs as Biomarkers in Cancer.Cancer management and research · 2021Review
- Efficacy, Safety, and Tumor Marker Inhibition of Apatinib Combined with Conventional Chemotherapy Regimens for Patients with Advanced Triple-Negative Breast Cancer.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA-compliant meta-analysis.Biomedical reports · 2020Article
- Long-Term Outcomes of Radical Surgery for Transverse Colon Cancer Staged from I to IIIC.Cancer management and research · 2020Article
- Liquid Biopsy of Extracellular Vesicle-Derived miR-193a-5p in Colorectal Cancer and Discovery of Its Tumor-Suppressor Functions.Frontiers in oncology · 2020Article
- Association betweenBMJ open · 2018Observational
- Evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder.Medicine · 2018Article
- Circulating exosomal miR-125a-3p as a novel biomarker for early-stage colon cancer.Scientific reports · 2017Article
- Nomograms for predicting the prognostic value of serological tumor biomarkers in colorectal cancer patients after radical resection.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distinction between breast cancer and benign breast diseases with nipple discharge remains an important diagnostic challenge. The purpose of this study was to predict the potential usefulness of tumor markers in nipple discharge and to investigate the relationship of tumor markers and clinical characteristics with breast cancer.One hundred and eleven patients with nipple discharge received breast surgery from November 2013 to December 2014 were included in the study. We evaluated levels of five tumor markers (CEA, CA153, CA199, CA724 and AFP) prior to treatment. Patients were divided into two groups according to postoperative pathological results: 30 cases in breast cancer group and 81 cases in benign group. The relationships of clinical characteristics with breast cancer were investigated by multivariate analysis with a logistic regression model.It showed significant differences in levels of nipple discharge CEA (P < 0.001) and CA153 (P = 0.014), but not CA199 (P = 0.856), CA724 (P = 0.171), AFP (P = 0.834) among two groups. Logistic regression analysis demonstrated complaint, age, menopause, abnormal palpable mass, CEA and CA153 were associated with breast cancer. In summary, measurements of CA199, CA724 and AFP in nipple discharge are not of great clinical value. Detecting CEA and CA153 in nipple dischargecould potentially be used for the early detection of breast cancer with in high-risk populations.
Indexed as
Identifiers
26885008PMC4723853W2409590833What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.