ArticleInternational journal of clinical and experimental medicine2015
Role of ornithine decarboxylase/polyamine pathway in focal cerebral ischemia-reperfusion injury and its mechanism in rats.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury.Frontiers in cellular neuroscience · 2022Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo observe the role of ornithine decarboxylase (ODC)/polyamine pathway in focal cerebral ischemia-reperfusion injury and to explore its mechanism in rats.
methodsThis study was randomly divided into 3 groups including sham-operation (sham) group, ischemia-reperfusion (I/R) group and α-difluoromethylornithine (DFMO) group (each group with 80 rats). In DFMO group, 300 mg/kg of DFMO was injected by tail vein 24 h before reperfusion. According to different time points (3 h, 12 h, 24 h, 48 h and 72 h) after reperfusion, each group was divided into 5 subgroups (each subgroup with 16 rats).
resultsIn I/R group, apoptosis began increasing 3 h after reperfusion, reached a peak 24 h after perfusion and began decreasing 48 h after perfusion. Compared with sham group, apoptosis significantly increased in I/R and DFMO groups (P<0.05). However, apoptosis was significantly lower in DFMO group than in I/R group at each time point (P<0.05). In I/R group, CHOP expression began increasing 3 h after reperfusion, reached a peak 24 h after perfusion and began decreasing 48 h after perfusion. CHOP expression was significantly lower in DFMO group than in I/R group at each time point (P<0.05). The level of polyamines was significantly higher in I/R and DFMO groups than in sham group, and in I/R group than in DFMO group 12 h, 24 h and 48 h, respectively (P<0.05).
conclusionDown-regulation of ODC/polyamine pathway may inhibit CHOP-mediated apoptosis caused by endoplasmic reticulum stress and plays a protective role in cerebral I/R injury.
Indexed as
Identifiers
26884982PMC4723827W2417751308What OpenQuestion holds
Registered trials
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