ArticleInternational journal of clinical and experimental medicine2015
The association of TGFB1 genetic polymorphisms with high myopia: a systematic review and meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Association between myopia and refractive parameters with eye behaviors in childhood aged 6 ~ 9 years: a follow-up study in Beijing.BMC public health · 2026Article
- Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1.Molecular medicine (Cambridge, Mass.) · 2024Article
- The Impact of Study-at-Home During the COVID-19 Pandemic on Myopia Progression in Chinese Children.Frontiers in public health · 2021Article
- Dynamic changes of periostin and collagen I in the sclera during progressive myopia in guinea pigs.Arquivos brasileiros de oftalmologia · 2020Article
- Atropine Differentially Modulates ECM Production by Ocular Fibroblasts, and Its Ocular Surface Toxicity Is Blunted by Colostrum.Biomedicines · 2020Article
- Changes in retinal metabolic profiles associated with form deprivation myopia development in guinea pigs.Scientific reports · 2017Article
- Expression and role of specificity protein 1 in the sclera remodeling of experimental myopia in guinea pigs.International journal of ophthalmology · 2017Article
- Insight into the molecular genetics of myopia.Molecular vision · 2017Review
- Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe TGFB1 gene is among the most studied genes in high myopia due to its role in scleral remodeling. But reported findings of association on TGFB1 and high myopia are inconsistent. This present study is to evaluate the association of TGFB1 polymorphisms and high myopia.
methodsA comprehensive literature search was conducted on studies published up to April 5, 2015. Summary odds ratios (ORs) and 95% confidence intervals were analyzed. Heterogeneity across studies was evaluated by Cochran Q statistic test and the I(2) index. Sensitivity analyses were conducted by the approach of one-study remove to assess the influence of single study on the combined effect.
resultsEight studies were included in this study for meta-analysis. Rs1982073 was associated with high myopia in dominant model (OR=1.64; 95% CI=1.04~2.58; P<0.05), heterozygous model (OR=1.54; 95% CI=1.02~2.33; P<0.05), homozygous model (OR=1.90; 95% CI=1.01~3.55; P=0.05) and allelic model (OR=1.36; 95% CI=1.01~1.84; P=0.05). However, there was no statistical significance when Bonferroni correction was considered. Rs4803455 was associated with high myopia in recessive model (OR=0.40; 95% CI=0.25~0.64; P<0.01) and homozygous model (OR=0.42; 95% CI=0.26~0.68; P<0.01). Rs1800469 was associated with high myopia in allelic model (OR=0.78; 95% CI=0.64~0.96; P<0.05). And the associations can withstand Bonferroni correction in models mentioned above when referring to rs4803455 (P<0.01) and rs1800469 (P<0.05).
conclusionsMeta-analysis of existing data revealed a suggestive association of TGFB1 rs1982073 and rs4803455 with high myopia.
Indexed as
Identifiers
26884952PMC4723797W2285435563What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.