ArticleInternational journal of clinical and experimental medicine2015
Phase-contrast imaging with synchrotron hard X-ray of micro lesions of the cartilage of the femoral head in rabbits.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- The Use of Synchrotron Radiation in the Medical Sciences.Photon science · 2026Article
- Phase-contrast imaging with synchrotron hard X-ray reveals the effect of icariin on bone tissue morphology and microstructure in rabbits with early glucocorticoid-induced osteonecrosis of the femoral head.Frontiers in cell and developmental biology · 2023Article
- 3D characterization of morphological changes in the intervertebral disc and endplate during aging: A propagation phase contrast synchrotron micro-tomography study.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo observe micro lesions on the cartilage of the rabbit femoral head using phase-contrast imaging with synchrotron hard X-ray and to prove that this method can be useful in the study of the degeneration of cartilage.
methodsNew Zealand white rabbits were used in a micro lesion model of rabbit femoral head cartilage. Bilateral femoral heads were excised from rabbits, and micro lesions were made on one side with a specially made knife with a blade 20 μm in width. The other femur was left intact to serve as the control. Phase-contrast imaging with synchrotron hard X-ray and conventional X-ray imaging were used to observe the cartilage. Histological changes were investigated using modified Golden tri-color staining.
resultsPhase-contrast imaging with synchrotron hard X-ray clearly showed the 20 μm lesions on the cartilage on the heads of rabbit femurs. These lesions were not visible with conventional X-ray imaging. Histological observation confirmed the presence of the microscopic lesions.
conclusionPhase-contrast imaging with synchrotron hard X-ray can detect microscopic lesions on cartilage that cannot be detected by conventional absorption-contrast X-ray. This provides an unequivocal, non-invasive alternative to histological examination in the diagnosis of joint disease. It should be considered a new tool in osteoarthritis and cartilage research.
Indexed as
Identifiers
26884921PMC4723766W2413969138What OpenQuestion holds
Registered trials
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