ArticleInternational journal of clinical and experimental pathology2015
siRNA-TMEM98 inhibits the invasion and migration of lung cancer cells.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- A Decade-Old Atlas of TMEM (Transmembrane) Protein Family in Lung Cancer: Lessons Learnt and Future Directions.International journal of molecular sciences · 2026Review
- Transmembrane protein TMEM98 as a multifunctional regulator in cancer: from signaling pathways to translational implications.Journal of translational medicine · 2025Review
- The role of TMEM59L in colorectal cancer progression and its interaction with the TGF-β/Smad pathway.Frontiers in oncology · 2025Article
- TMEM229A suppresses non‑small cell lung cancer progression via inactivating the ERK pathway.Oncology reports · 2021Article
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- The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.PLoS genetics · 2020Article
- Article
- Missense Mutations in the Human Nanophthalmos Gene TMEM98 Cause Retinal Defects in the Mouse.Investigative ophthalmology & visual science · 2019Article
- MIS416 as a siRNA Delivery System with the Ability to Target Antigen-Presenting Cells.Nucleic acid therapeutics · 2018Article
- TMEM Proteins in Cancer: A Review.Frontiers in pharmacology · 2018Review
- Inhibition of IL-8-mediated endothelial adhesion, VSMCs proliferation and migration by siRNA-TMEM98 suggests TMEM98's emerging role in atherosclerosis.Oncotarget · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-small cell lung cancer (NSCLC) is one of the most common human malignancies, which threatens people's life heavily. Recently, TMEM98 is supposed to be of great value for the discoveries of anti-tumor drugs. We attempt to explore the biological role of TMEM98 in the human lung carcinoma. Clinical lung cancer tissue and normal tissue were collected, and the mRNA expression of TMEM98 in cancer tissue was significantly higher than that in normal tissue. By real-time-PCR and Western blot analysis of TMEM98 expression, human A549 and H460 cells were determined to carry out further investigations. By CCK8, it is found that siRNA-TMEM98 treatment effectively suppressed the proliferation of A549 and H460 cells. In addition, the invasion and migration of A549 and H460 cells were also inhibited by siRNA-TMEM98. We then studied the invasion and migration related proteins level by Western blot. From our result, the protein expression of MMP-2, MMP-9, RhoC and MTA1 were all regulated dramatically in siRNA-TMEM98 groups compared with the control and mock group. To conclude, our results indicated that siRNA-TMEM98 inhibited the invasion and migration of lung cancer cells, which can be considered as a novel target for NSCLC treatment.
Indexed as
Identifiers
26884835PMC4730048W2394728300What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.