Evidence map›Paper›PMID 26884824›Full record

ArticleInternational journal of clinical and experimental pathology2015

Relationship between the gene polymorphisms of kallikrein-kinin system and Alzheimer's disease in a Hunan Han Chinese population.

Yanyao Deng, Deren Hou, Mi Tian, Wei Li, Xialu Feng, Zhuling Yu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yanyao DengDepartment of Neurology, The Third Xiangya Hospital, Central South UniversityChangsha, China; Department of Neurology, The First Hospital of ChangshaChangsha, China.
Deren HouDepartment of Neurology, The Third Xiangya Hospital, Central South University Changsha, China.
Mi TianDepartment of Neurology, The Third Xiangya Hospital, Central South University Changsha, China.
Wei LiDepartment of Neurology, The Third Xiangya Hospital, Central South UniversityChangsha, China; Department of Neurology, The First Hospital of ChangshaChangsha, China.
Xialu FengDepartment of Neurology, The Third Xiangya Hospital, Central South University Changsha, China.
Zhuling YuDepartment of Neurology, The Third Xiangya Hospital, Central South University Changsha, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to determine the connection between polymorphisms of kallikrein kinin system including KLK1 (rs5516), KNG1 (rs710446, rs2304456) and ACE (rs4291, rs4309, rs4343) and late-onset Alzheimer's disease (LOAD). The research was conducted as a case-control study, comprising 201 AD patients in the AD group, and 257 healthy subjects as the control group. PCR amplification and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) were used to detect the six polymorphisms (rs5516 in KLK1; rs710446, rs2304456 in KNG1; rs4291, rs4309, rs4343 in ACE) from both groups. No statistically significant difference was found between the genotype and allelotype distributions of rs5516, rs710446, rs2304456, rs4291 and rs4343 (P>0.05). The differences between the genotype and allelotype distributions of the rs4309 were statistically significant (P<0.05). Haplotype analysis confirmed the existence of three haplotypes (AG, AT, GT) composed of rs710446/rs2304456, and six haplotypes (ATA, ACA, TCA, TCG, TTA, TTG) composed of rs4291/rs4309/rs4343, among which the distribution of ATA, ACA, TCA between the two groups was statistically significant difference (P<0.05). Our study showed that the polymorphisms of rs5516, rs710446, rs2304456, rs4291 and rs4343 is not related to the incidence of LOAD. The polymorphisms of rs4309 may be related to LOAD, as well as ATA, ACA, and TCA haplotype composed of rs4291/rs4309/rs4343.

Indexed as

Polymorphism, Single NucleotideAgedAged, 80 and overAlzheimer DiseaseAsian PeopleCase-Control StudiesChinaFemaleGene FrequencyGenetic Association StudiesGenetic MarkersGenetic Predisposition to DiseaseHaplotypesHeterozygoteHomozygoteHumansACE protein, humanGenetic MarkersKallikreinsKininogensKNG1 protein, humanPeptidyl-Dipeptidase AAlzheimer’s diseasegenekallikrein-kinin systempolymorphism

Identifiers

PMID26884824
PMCPMC4730037
OpenAlexW2415321929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.