Evidence map›Paper›PMID 26884815›Full record

ArticleDiabetology & metabolic syndrome2016

Neck circumference as a risk factor of screen-detected diabetes mellitus: community-based study.

Mykolay Khalangot, Vitaliy Gurianov, Nadia Okhrimenko, Igor Luzanchuk, Victor Kravchenko

Abstract read
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Article in Diabetology & metabolic syndrome, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

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18citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mykolay KhalangotShupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine ; Komisarenko Institute of Endocrinology and Metabolism, Vyshgorodska 69, Kiev, 04114 Ukraine.
Vitaliy GurianovBohomolets National Medical University, Kiev, Ukraine.
Nadia OkhrimenkoKomisarenko Institute of Endocrinology and Metabolism, Vyshgorodska 69, Kiev, 04114 Ukraine.
Igor LuzanchukKomisarenko Institute of Endocrinology and Metabolism, Vyshgorodska 69, Kiev, 04114 Ukraine.
Victor KravchenkoKomisarenko Institute of Endocrinology and Metabolism, Vyshgorodska 69, Kiev, 04114 Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhereas an increase of neck circumference (NC) had been recently identified as a new independent cardiovascular disease (CVD) and metabolic syndrome risk factor, similar assessments concerning screen-detected diabetes mellitus (SDDM) have not been made. Thyroid gland volume (ThV) can potentially affect NC however the significance of this influence concerning the risk of NC-related disease is unknown.

methodsWe performed a ThV-adjusted evaluation of NC within a population-based investigation of SDDM and impaired glucose regulation (IGR) prevalence. This study contains fasting plasma glucose (FPG) and 75 g 2-h glucose tolerance test results (2-hPG) of 196 residents of Kyiv region, Ukraine, randomly selected from the rural population older than 44 y.o. who were not registered as diabetes mellitus patients. Standard anthropometric (height; weight; blood pressure; waist, hip circumferences), NC and ultrasonography ThV measurements were performed, hypotensive medication, CVD events and early life nutrition history considered. HbA1c was measured, if FPG/2-hPG reached 7.0/11.1 mmol/l respectively; HbA1c level 6.5 % was considered to be SDDM diagnostic; IGR if FPG/2-hPG reached 6.1/7.8 but less than 7.0/11.1 mmol/l respectively.

resultsNeck circumference among women with normal FPG/2-hPG was 35 (33-36) cm, IGR 36 (34.5-38) cm, SDDM HbA1c < 6.5 % 42 (40-43) cm, HbA1c > 6.5 % 42.5 (40-44) cm, p < 0.001, and for men from the same groups 38.5 (36.5-41.5) cm; 39 (37-42) cm; 42 (40-43) cm; 42.5 (40-44) cm, p = 0.063; medians (QI-QIII). Gender-adjusted logistic regression OR for SDDM HbA1c > 6.5 % vs. normal FPG/2-hPG category depending of NC as a continued variable, equaled to 1.60 (95 % CI 1.27-2.02) per cm. Additional adjusting by ThV, body mass or waist/hip index, high blood pressure, acute CVD events, or starvation history did not significantly influence this risk.

conclusionNeck circumference is a new risk factor of SDDM that is independent from other indicators of adipose tissue distribution as well as from the ThV.

Indexed as

Body mass indexNeck circumferenceRisk factorScreen-detected diabetes mellitusThyroid gland volumeWaist to hip index

Identifiers

PMID26884815
PMCPMC4754805

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