ArticleThe Journal of heredity2016
The MC1R and ASIP Coat Color Loci May Impact Behavior in the Horse.
Article in The Journal of heredity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Integrating landscape genomics and machine learning to analyze the genetic structure and specific molecular markers of Chinese dairy goats (Capra hircus).Journal of animal science and biotechnology · 2026Article
- Behavior in Australian Shepherd Dogs Assessed Using the C-BARQ: A Preliminary Study of Associations with Coat Color, Sex, and Neutering Status.Veterinary sciences · 2026Article
- Identification of TYR gene variants associated with white coat color in Hanwoo cattle using whole-genome sequencing.BMC genomics · 2026Article
- Non-Synonymous Substitutions in Cadherin 13, Solute Carrier Family 6 Member 4, and Monoamine Oxidase A Genes are Associated with Personality Traits in Thoroughbred Horses.Behavior genetics · 2024Article
- Phenotypic and Genetic Study of the Presence of Hair Whorls in Pura Raza Español Horses.Animals : an open access journal from MDPI · 2023Article
- Investigating the Market Value of Brumbies (Animals : an open access journal from MDPI · 2023Article
- Identification of Personality-Related Candidate Genes in Thoroughbred Racehorses Using a Bioinformatics-Based Approach Involving Functionally Annotated Human Genes.Animals : an open access journal from MDPI · 2023Article
- Determination of breeding criteria for gait proficiency in leisure riding and racing dromedary camels: a stepwise multivariate analysis of factors predicting overall biomechanical performance.Frontiers in veterinary science · 2023Article
- Basal Reactivity Evaluated by Infrared Thermography in the "Caballo de Deporte Español" Horse Breed According to Its Coat Color.Animals : an open access journal from MDPI · 2022Article
- Morpho-Functional Traits in Pura Raza Menorquina Horses: Genetic Parameters and Relationship with Coat Color Variables.Animals : an open access journal from MDPI · 2022Article
- GWAS Identifies a Region Containing the SALL1 Gene in Variation of Pigmentation Intensity Within the Chestnut Coat Color of Horses.The Journal of heredity · 2021Article
- Article
- Genetic association with boldness and maternal performance in a free-ranging population of grey seals (Halichoerus grypus).Heredity · 2021Article
- From the Eurasian Steppes to the Roman Circuses: A Review of Early Development of Horse Breeding and Management.Animals : an open access journal from MDPI · 2021Review
- Influence of coat color on genetic parameter estimates in horses.Journal of applied genetics · 2021Article
- Inconsistencies in horse coat color registration: A case study.Journal of equine science · 2020Article
- An Independent Locus Upstream ofGenes · 2020Article
- Perspectives on two temperamental biases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
Corrections and comments
- Erratum issuedErratum.2016
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shared signaling pathways utilized by melanocytes and neurons result in pleiotropic traits of coat color and behavior in many mammalian species. For example, in humans polymorphisms at MC1R cause red hair, increased heat sensitivity, and lower pain tolerance. In deer mice, rats, and foxes, ASIP polymorphisms causing black coat color lead to more docile demeanors and reduced activity. Horse (Equus caballus) base coat color is primarily determined by polymorphisms at the Melanocortin-1 Receptor (MC1R) and Agouti Signaling Protein (ASIP) loci, creating a black, bay, or chestnut coat. Our goal was to investigate correlations between genetic loci for coat color and temperament traits in the horse. We genotyped a total of 215 North American Tennessee Walking Horses for the 2 most common alleles at the MC1R (E/e) and ASIP (A/a) loci using previously published PCR and RFLP methods. The horses had a mean age of 10.5 years and comprised 83 geldings, 25 stallions, and 107 mares. To assess behavior, we adapted a previously published survey for handlers to score horses from 1 to 9 on 20 questions related to specific aspects of temperament. We utilized principle component analysis to combine the individual survey scores into 4 factors of variation in temperament phenotype. A factor component detailing self-reliance correlated with genotypes at the ASIP locus; black mares (aa) were more independent than bay mares (A_) (P = 0.0063). These findings illuminate a promising and novel animal model for future study of neuroendocrine mechanisms in complex behavioral phenotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.