ArticleJournal of experimental botany2016
Formation of β-glucogallin, the precursor of ellagic acid in strawberry and raspberry.
Article in Journal of experimental botany, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 58 citations in OpenAlex.
- Inheritance and enzymatic basis of anthocyanin malonylation in Fragaria × ananassa.The Plant journal : for cell and molecular biology · 2025Article
- Key genes in a "Galloylation-Degalloylation cycle" controlling the synthesis of hydrolyzable tannins in strawberry plants.Horticulture research · 2025Article
- Antioxidant, Anti-Inflammatory, and Oral Bioavailability of Novel Sulfonamide Derivatives of Gallic Acid.Antioxidants (Basel, Switzerland) · 2025Article
- Elucidation and reconstitution of hydrolyzable tannin biosynthesis.Plant biotechnology (Tokyo, Japan) · 2024Article
- Identification of MYB Transcription Factor, a Regulator Related to Hydrolysable Tannin Synthesis inPlants (Basel, Switzerland) · 2024Article
- First Data on the (Poly)phenolic Profiling of Farmacista Honorati Persimmon Fruit (Plants (Basel, Switzerland) · 2024Article
- Genome-wide investigation of UDP-Glycosyltransferase family in Tartary buckwheat (Fagopyrum tataricum).BMC plant biology · 2024Article
- Chemodiversity of Arctic PlantPlants (Basel, Switzerland) · 2024Article
- Quantitative trait loci mapping of polyphenol metabolites from a 'Latham' x 'Glen Moy' red raspberry (Rubus idaeus L) cross.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Metabolites ofMetabolites · 2023Article
- Metabolites of Siberian Raspberries: LC-MS Profile, Seasonal Variation, Antioxidant Activity and, Thermal Stability ofPlants (Basel, Switzerland) · 2021Article
- Identification and Characterization of Glucosyltransferase That Forms 1-Galloyl-Molecules (Basel, Switzerland) · 2021Article
- Exploitation ofMolecules (Basel, Switzerland) · 2021Article
- Characterizing the involvement of FaMADS9 in the regulation of strawberry fruit receptacle development.Plant biotechnology journal · 2020Article
- Major-effect candidate genes identified in cultivated strawberry (Horticulture research · 2020Article
- Semirational design and engineering of grapevine glucosyltransferases for enhanced activity and modified product selectivity.Glycobiology · 2019Article
- Novel biotechnological glucosylation of high-impact aroma chemicals, 3(2H)- and 2(5H)-furanones.Scientific reports · 2019Article
- Early metabolic and transcriptional variations in fruit of natural white-fruited Fragaria vesca genotypes.Scientific reports · 2017Article
- Clarifying sub-genomic positions of QTLs for flowering habit and fruit quality in U.S. strawberry (Horticulture research · 2017Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ellagic acid/ellagitannins are plant polyphenolic antioxidants that are synthesized from gallic acid and have been associated with a reduced risk of cancer and cardiovascular diseases. Here, we report the identification and characterization of five glycosyltransferases (GTs) from two genera of the Rosaceae family (Fragaria and Rubus; F. × ananassa FaGT2*, FaGT2, FaGT5, F. vesca FvGT2, and R. idaeus RiGT2) that catalyze the formation of 1-O-galloyl-β-D-glucopyranose (β-glucogallin) the precursor of ellagitannin biosynthesis. The enzymes showed substrate promiscuity as they formed glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids. Determination of kinetic values and site-directed mutagenesis revealed amino acids that affected substrate preference and catalytic activity. Green immature strawberry fruits were identified as the main source of gallic acid, β-glucogallin, and ellagic acid in accordance with the highest GT2 gene expression levels. Injection of isotopically labeled gallic acid into green fruits of stable transgenic antisense FaGT2 strawberry plants clearly confirmed the in planta function. Our results indicate that GT2 enzymes might contribute to the production of ellagic acid/ellagitannins in strawberry and raspberry, and are useful to develop strawberry fruit with additional health benefits and for the biotechnological production of bioactive polyphenols.
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