ArticlePlant physiology2016
Singlet Oxygen-Induced Membrane Disruption and Serpin-Protease Balance in Vacuolar-Driven Cell Death.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Biomaterial-based Drug delivery strategies for head and neck cancer: Local delivery, combination therapy, and translational challenges.International journal of pharmaceutics: X · 2026Review
- EXECUTER-mediated singlet oxygen signaling in plants: Mechanisms, evolution, and functional diversification.Plant communications · 2026Review
- SsPit2A/B Effectors fromPlants (Basel, Switzerland) · 2026Article
- Singlet Oxygen Generation and Signaling in Higher Plants.International journal of molecular sciences · 2026Review
- Perovskite-based photocatalysis for microbial inactivation: materials, mechanisms, and challenges.Nanoscale advances · 2026Review
- Article
- Effect of Singlet Oxygen on the Stomatal and Cell Wall of Rice Seedling Under Different Stresses.International journal of molecular sciences · 2025Article
- A Holistic Investigation of Arabidopsis Proteomes Altered in Chloroplast Biogenesis and Retrograde Signalling Identifies PsbO as a Key Regulator of Chloroplast Quality Control.Plant, cell & environment · 2025Article
- TcSERPIN, an inhibitor that interacts with cocoa defense proteins and has biotechnological potential against human pathogens.Frontiers in plant science · 2024Article
- A hidden demethylation pathway removes mercury from rice plants and mitigates mercury flux to food chains.Nature food · 2024Article
- Plant Serpins: Potential Inhibitors of Serine and Cysteine Proteases with Multiple Functions.Plants (Basel, Switzerland) · 2023Review
- β-Cyclocitral: Emerging Bioactive Compound in Plants.Molecules (Basel, Switzerland) · 2022Review
- Proteome Phenotypes Discriminate the Growing Location and Malting Traits in Field-Grown Barley.Journal of agricultural and food chemistry · 2022Article
- Article
- Plastid and cytoplasmic origins ofFrontiers in plant science · 2022Article
- Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A Comprehensive Phylogenetic Analysis of the Serpin Superfamily.Molecular biology and evolution · 2021Article
- Lipoxygenase functions in 1O2 production during root responses to osmotic stress.Plant physiology · 2021Article
- Engineering of fluorescent or photoactive Trojan probes for detection and eradication of β-Amyloids.Drug delivery · 2020Article
- Genome Wide Identification and Comparative Analysis of the Serpin Gene Family in Brachypodium and Barley.Plants (Basel, Switzerland) · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Singlet oxygen plays a role in cellular stress either by providing direct toxicity or through signaling to initiate death programs. It was therefore of interest to examine cell death, as occurs in Arabidopsis, due to differentially localized singlet oxygen photosensitizers. The photosensitizers rose bengal (RB) and acridine orange (AO) were localized to the plasmalemma and vacuole, respectively. Their photoactivation led to cell death as measured by ion leakage. Cell death could be inhibited by the singlet oxygen scavenger histidine in treatments with AO but not with RB In the case of AO treatment, the vacuolar membrane was observed to disintegrate. Concomitantly, a complex was formed between a vacuolar cell-death protease, RESPONSIVE TO DESSICATION-21 and its cognate cytoplasmic protease inhibitor ATSERPIN1. In the case of RB treatment, the tonoplast remained intact and no complex was formed. Over-expression of AtSerpin1 repressed cell death, only under AO photodynamic treatment. Interestingly, acute water stress showed accumulation of singlet oxygen as determined by fluorescence of Singlet Oxygen Sensor Green, by electron paramagnetic resonance spectroscopy and the induction of singlet oxygen marker genes. Cell death by acute water stress was inhibited by the singlet oxygen scavenger histidine and was accompanied by vacuolar collapse and the appearance of serpin-protease complex. Over-expression of AtSerpin1 also attenuated cell death under this mode of cell stress. Thus, acute water stress damage shows parallels to vacuole-mediated cell death where the generation of singlet oxygen may play a role.
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