ArticleThe American journal of pathology1989
Diagnosis of myelomonocytic and macrophage neoplasms in routinely processed tissue biopsies with monoclonal antibody KP1.
Article in The American journal of pathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 91 citations in OpenAlex.
- Telocytes: a potential defender in the spleen of Npc1 mutant mice.Journal of cellular and molecular medicine · 2017Article
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- Relapse of acute myeloid leukemia manifested by cholecystitis: A case report and review of the literature.International journal of surgery case reports · 2014Article
- Innate immune reactions in locally limited tonsillar cancer.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Identification of CD68(+) neutrophil granulocytes in in vitro model of acute inflammation and inflammatory bowel disease.International journal of clinical and experimental pathology · 2013Article
- Monocyte/Macrophage-specific marker CD163+ histiocytic sarcoma: case report with clinical, morphologic, immunohistochemical, and molecular genetic studies.International journal of hematology · 2004Article
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- Monoclonality of smooth muscle cells in human atherosclerosis.The American journal of pathology · 1997Article
- Pre- and post-embedding immunoelectron microscopy of Ki-M1P immunoreactive germinal center macrophages using ultra-small gold probes with silver enhancement.Histochemistry and cell biology · 1996Article
- A new monoclonal antibody (3A5) that recognises a fixative resistant epitope on tissue macrophages and monocytes.Journal of clinical pathology · 1994Article
- KP-1: not a specific marker. Staining of 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes.Virchows Archiv : an international journal of pathology · 1994Review
- Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells.International journal of pancreatology : official journal of the International Association of Pancreatology · 1993Article
- PG-M1: a new monoclonal antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the CD68 molecule.The American journal of pathology · 1993Article
- CD68 reactivity of non-macrophage derived tumours in cytological specimens.Journal of clinical pathology · 1993Article
- Expression of vascular cell adhesion molecule (VCAM-1) in liver and pancreas allograft rejection.The American journal of pathology · 1993Article
- Immunohistochemical evaluation of bone marrow lymphoid nodules in chronic myeloproliferative disorders.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Article
- Immunohistochemical characterization of Ki-M6 monoclonal antibody in Bouin-fixed, paraffin-embedded sections of normal and neoplastic human tissues.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Article
- Use of monoclonal antibody KP1 for identifying normal and neoplastic human mast cells.Journal of clinical pathology · 1990Article
- Immunohistochemical study of the abnormal cells in Langerhans cell histiocytosis (histiocytosis x).Virchows Archiv. A, Pathological anatomy and histopathology · 1990Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A new monoclonal antibody, KP1, against the CD68 antigen, which labels macrophages and other members of the mononuclear phagocyte lineage in routinely processed tissue sections, has been used to stain a range of lymphoid, histiocytic, and myelomonocytic proliferations. All 20 neoplasms of myeloid, myelomonocytic, and presumed macrophage derivation reacted with antibody KP1. None of the 22 cases of T cell neoplasia had positive reactions. Although 14 of 41 B lineage lymphomas and leukaemias were stained by antibody KP1, staining was usually confined to small dots of reactivity, in contrast to the strong and extensive cytoplasmic staining seen in the neoplasms of myeloid and macrophage/monocyte origin. Furthermore, positive B cell neoplasms were almost all small cell proliferations, which are unlikely to be confused with myelomonocytic malignancies. It was concluded that antibody KP1 is a valuable addition to a panel of monoclonal antibodies for phenotyping lymphomas, particularly in routinely fixed tissues. It should assist the pathologist in the recognition of extramedullary presentation of leukaemia, aid in the diagnosis of suspected cases of true histiocytic neoplasia, and allow for quantitation of macrophages infiltrating lymphomas and other solid tumors.
Indexed as
Identifiers
2688430PMC1880478W294037837What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.