ArticleProceedings of the National Academy of Sciences of the United States of America2016
Sex-specific regulation of Lgr3 in Drosophila neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
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- Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.Cell genomics · 2026Article
- Organization and evolution of sex-biased gene expression inbioRxiv : the preprint server for biology · 2026Article
- Social experience shapes fighting strategies ineLife · 2025Article
- Sexually-dimorphic neurons in theResearch square · 2025Article
- Sexually-dimorphic neurons in thebioRxiv : the preprint server for biology · 2025Article
- Receptor deorphanization in starfish reveals the evolution of relaxin signaling as a regulator of reproduction.BMC biology · 2025Article
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- Cellular sex throughout the organism underlies somatic sexual differentiation.Nature communications · 2024Article
- The diverse roles of insulin signaling in insect behavior.Frontiers in insect science · 2024Review
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- A modular circuit architecture coordinates the diversification of courtship strategies inbioRxiv : the preprint server for biology · 2023Article
- Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion.bioRxiv : the preprint server for biology · 2023Article
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- Single-cell transcriptome profiles ofeLife · 2023Article
- Insulin-like peptide 8 (Ilp8) regulates female fecundity in flies.Frontiers in cell and developmental biology · 2023Article
- Endocrine Regulation of Lifespan in Insect Diapause.Frontiers in physiology · 2022Review
- Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.PLoS genetics · 2021Article
- Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization.PLoS genetics · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
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Abstract
The development of sexually dimorphic morphology and the potential for sexually dimorphic behavior in Drosophila are regulated by the Fruitless (Fru) and Doublesex (Dsx) transcription factors. Several direct targets of Dsx have been identified, but direct Fru targets have not been definitively identified. We show that Drosophila leucine-rich repeat G protein-coupled receptor 3 (Lgr3) is regulated by Fru and Dsx in separate populations of neurons. Lgr3 is a member of the relaxin-receptor family and a receptor for Dilp8, necessary for control of organ growth. Lgr3 expression in the anterior central brain of males is inhibited by the B isoform of Fru, whose DNA binding domain interacts with a short region of an Lgr3 intron. Fru A and C isoform mutants had no observed effect on Lgr3 expression. The female form of Dsx (Dsx(F)) separately up- and down-regulates Lgr3 expression in distinct neurons in the abdominal ganglion through female- and male-specific Lgr3 enhancers. Excitation of neural activity in the Dsx(F)-up-regulated abdominal ganglion neurons inhibits female receptivity, indicating the importance of these neurons for sexual behavior. Coordinated regulation of Lgr3 by Fru and Dsx marks a point of convergence of the two branches of the sex-determination hierarchy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.