ArticleProceedings of the National Academy of Sciences of the United States of America2016
Phagocytosis genes nonautonomously promote developmental cell death in the Drosophila ovary.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 72 citations in OpenAlex.
- Comparative analysis of draper mutant alleles and RNAi expression systems in the ovary and brain of Drosophila melanogaster.G3 (Bethesda, Md.) · 2026Article
- Danger at the border: Rac turns nibblers into murderers.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hyperactive Rac converts sublethal to lethal trogocytosis in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Uev1A counteracts oncogeniceLife · 2026Article
- Macrophages regulate meiotic initiation and germ cell clearance in the developing ovary.bioRxiv : the preprint server for biology · 2026Article
- Reorganization of E-cadherin into apical spot junctions mediates interlineage adhesion between epithelial and germline cells.Frontiers in cell and developmental biology · 2026Article
- Hyperactive Rac converts sublethal nibbling to lethal phagocytosisbioRxiv : the preprint server for biology · 2025Article
- Ecdysone signaling-induced dumpless1 expression controls nurse cell dumping in Drosophila oogenesis.Nature communications · 2025Article
- Ecdysone regulates phagocytic cell fate of epithelial cells in developing Drosophila eggs.The Journal of cell biology · 2025Article
- Polyploidy promotes transformation of epithelial cells into nonprofessional phagocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Diverse roles of stress-responsive RNP granules in oogenesis and infertility.Biology of reproduction · 2025Review
- GATA factor Serpent promotes phagocytosis in non-professional phagocytes during Drosophila oogenesis.Development (Cambridge, England) · 2025Article
- Multi-modal comparison of molecular programs driving nurse cell death and clearance in Drosophila melanogaster oogenesis.PLoS genetics · 2025Article
- Sacrificing cells of the cyst: non-apoptotic cell death in germline cysts via acidification.Frontiers in cell death · 2025Article
- Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila.Current biology : CB · 2024Article
- Cell death by phagocytosis.Nature reviews. Immunology · 2024Review
- Finishing the egg.Genetics · 2024Article
- Professional phagocytes are recruited for the clearance of obsolete nonprofessional phagocytes in theFrontiers in immunology · 2024Article
- Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability inbioRxiv : the preprint server for biology · 2023Article
- Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo.Immunological reviews · 2023Review
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
Programmed cell death (PCD) is usually considered a cell-autonomous suicide program, synonymous with apoptosis. Recent research has revealed that PCD is complex, with at least a dozen cell death modalities. Here, we demonstrate that the large-scale nonapoptotic developmental PCD in the Drosophila ovary occurs by an alternative cell death program where the surrounding follicle cells nonautonomously promote death of the germ line. The phagocytic machinery of the follicle cells, including Draper, cell death abnormality (Ced)-12, and c-Jun N-terminal kinase (JNK), is essential for the death and removal of germ-line-derived nurse cells during late oogenesis. Cell death events including acidification, nuclear envelope permeabilization, and DNA fragmentation of the nurse cells are impaired when phagocytosis is inhibited. Moreover, elimination of a small subset of follicle cells prevents nurse cell death and cytoplasmic dumping. Developmental PCD in the Drosophila ovary is an intriguing example of nonapoptotic, nonautonomous PCD, providing insight on the diversity of cell death mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.