ArticleProceedings of the National Academy of Sciences of the United States of America2016
Arabidopsis type B cytokinin response regulators ARR1, ARR10, and ARR12 negatively regulate plant responses to drought.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 1 of them a synthesis that pooled it.
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Who cites it
113 citing papers in PubMed, 1 synthesis or guideline pooled it, 266 citations in OpenAlex.
- Abiotic Stress in Crop Production.International journal of molecular sciences · 2023Pooled it
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- Discovery of specific rhizosphere bacteriaScience advances · 2026Article
- Brassinosteroid-mediated stress adaptation and signaling networks in Brassicaceae crops.Planta · 2026Review
- Biotechnological modification of the cytokinin regulatory system to improve drought and heat tolerance in the major crops.Plant cell reports · 2026Review
- Genome-wide identification of tomato B-RRs gene family and expression analysis in response to ABA and drought.PloS one · 2026Article
- Cytokinin derivatives as tools to enhance plant stress resilience.Frontiers in plant science · 2026Review
- Nitrogen deficiency restricts gall development by altering metabolic and hormonal networks inFrontiers in plant science · 2026Article
- Decoding drought tolerance from a genomic approach in Castanea sativa Mill.The plant genome · 2025Article
- Genome-wide identification and expression analysis of the GARP superfamily in response to abiotic stresses in alfalfa (Medicago sativa L.).BMC plant biology · 2025Article
- Identification of BoRR gene family in cauliflower: roles in curd development and salt tolerance.BMC genomics · 2025Article
- Geminiviral replication enhancer hijacks a negative regulator of cytokinin signaling to facilitate viral infection.Plant communications · 2025Article
- To grow or not to grow: the enigma of plant root growth dynamism.Plant molecular biology · 2025Review
- Genome-wide identification and analysis of SmRR gene family in eggplant (Solanum melongena L.) and their response to abiotic stress and auxin.BMC genomics · 2025Article
- Genomic Insights intoInternational journal of molecular sciences · 2025Article
- Comparative Genomic Analysis of the Poaceae Cytokinin Response RegulatorInternational journal of molecular sciences · 2025Article
- Dressed Up to the Nines: The Interplay of Phytohormones Signaling and Redox Metabolism During Plant Response to Drought.Plants (Basel, Switzerland) · 2025Review
- Genome-wide identification and functional characterization of the two-component system gene family in petunia reveals roles in hormone signaling and stress response.Frontiers in plant science · 2025Article
- Seed yield and nutrition in slow-wilting soybean breeding lines as influenced by irrigated and non-irrigated conditions in the Midsouth USA.Frontiers in plant science · 2025Article
- The TATA-box binding protein-associated factor TAF12b facilitates the degradation of type B response regulators to negatively regulate cytokinin signaling.Plant communications · 2024Article
53 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we used a loss-of-function approach to elucidate the functions of three Arabidopsis type B response regulators (ARRs)--namely ARR1, ARR10, and ARR12--in regulating the Arabidopsis plant responses to drought. The arr1,10,12 triple mutant showed a significant increase in drought tolerance versus WT plants, as indicated by its higher relative water content and survival rate on drying soil. This enhanced drought tolerance of arr1,10,12 plants can be attributed to enhanced cell membrane integrity, increased anthocyanin biosynthesis, abscisic acid (ABA) hypersensitivity, and reduced stomatal aperture, but not to altered stomatal density. Further drought-tolerance tests of lower-order double and single mutants indicated that ARR1, ARR10, and ARR12 negatively and redundantly control plant responses to drought, with ARR1 appearing to bear the most critical function among the three proteins. In agreement with these findings, a comparative genome-wide analysis of the leaves of arr1,10,12 and WT plants under both normal and dehydration conditions suggested a cytokinin (CK) signaling-mediated network controlling plant adaptation to drought via many dehydration/drought- and/or ABA-responsive genes that can provide osmotic adjustment and protection to cellular and membrane structures. Expression of all three ARR genes was repressed by dehydration and ABA treatments, inferring that plants down-regulate these genes as an adaptive mechanism to survive drought. Collectively, our results demonstrate that repression of CK response, and thus CK signaling, is one of the strategies plants use to cope with water deficit, providing novel insight for the design of drought-tolerant plants by genetic engineering.
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