ArticleProceedings of the National Academy of Sciences of the United States of America2016
A virus of hyperthermophilic archaea with a unique architecture among DNA viruses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Novel polymycoviruses are encapsidated in filamentous virions.Journal of virology · 2025Article
- Archaeal virus entry and egress.microLife · 2024Review
- A compendium of viruses from methanogenic archaea reveals their diversity and adaptations to the gut environment.Nature microbiology · 2023Article
- Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery.Nature communications · 2023Article
- Article
- Review
- Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The structures of two archaeal type IV pili illuminate evolutionary relationships.Nature communications · 2020Article
- New virus isolates from Italian hydrothermal environments underscore the biogeographic pattern in archaeal virus communities.The ISME journal · 2020Article
- Structure of a filamentous virus uncovers familial ties within the archaeal virosphere.Virus evolution · 2020Article
- Spindle-shaped viruses infect marine ammonia-oxidizing thaumarchaea.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- New archaeal viruses discovered by metagenomic analysis of viral communities in enrichment cultures.Environmental microbiology · 2019Article
- ICTV Virus Taxonomy Profile: Tristromaviridae.The Journal of general virology · 2019Article
- Biotechnology of extremely thermophilic archaea.FEMS microbiology reviews · 2018Review
- Comparative genetic and genomic analysis of the novel fusellovirus Sulfolobus spindle-shaped virus 10.Virus evolution · 2018Article
- Novel Sulfolobus Virus with an Exceptional Capsid Architecture.Journal of virology · 2018Article
- Viruses of archaea: Structural, functional, environmental and evolutionary genomics.Virus research · 2018Review
- Methanosarcina Spherical Virus, a Novel Archaeal Lytic Virus Targeting Methanosarcina Strains.Journal of virology · 2017Article
- The enigmatic archaeal virosphere.Nature reviews. Microbiology · 2017Review
- Isolation and Characterization of Metallosphaera Turreted Icosahedral Virus, a Founding Member of a New Family of Archaeal Viruses.Journal of virology · 2017Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viruses package their genetic material in diverse ways. Most known strategies include encapsulation of nucleic acids into spherical or filamentous virions with icosahedral or helical symmetry, respectively. Filamentous viruses with dsDNA genomes are currently associated exclusively with Archaea. Here, we describe a filamentous hyperthermophilic archaeal virus, Pyrobaculum filamentous virus 1 (PFV1), with a type of virion organization not previously observed in DNA viruses. The PFV1 virion, 400 ± 20 × 32 ± 3 nm, contains an envelope and an inner core consisting of two structural units: a rod-shaped helical nucleocapsid formed of two 14-kDa major virion proteins and a nucleocapsid-encompassing protein sheath composed of a single major virion protein of 18 kDa. The virion organization of PFV1 is superficially similar to that of negative-sense RNA viruses of the family Filoviridae, including Ebola virus and Marburg virus. The linear dsDNA of PFV1 carries 17,714 bp, including 60-bp-long terminal inverted repeats, and contains 39 predicted ORFs, most of which do not show similarities to sequences in public databases. PFV1 is a lytic virus that completely disrupts the host cell membrane at the end of the infection cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.