Trial reportMolecular imaging and biology2016
Improvements in PET Image Quality in Time of Flight (TOF) Simultaneous PET/MRI.
Trial report in Molecular imaging and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Will PET/MR Imaging Replace PET/CT for Pediatric Applications?Diagnostics (Basel, Switzerland) · 2025Review
- Influences on PET Quantification and Interpretation.Diagnostics (Basel, Switzerland) · 2022Review
- One-stop local and whole-body staging of children with cancer.Pediatric radiology · 2022Review
- Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study toCancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- [Timing calibration comparison research of integrated TOF-PET/MR].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Article
- An edge-readout, multilayer detector for positron emission tomography.Medical physics · 2018Article
- Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneousEJNMMI research · 2018Article
- Initial experience with a SiPM-based PET/CT scanner: influence of acquisition time on image quality.EJNMMI physics · 2018Article
- How to Provide Gadolinium-Free PET/MR Cancer Staging of Children and Young Adults in Less than 1 h: the Stanford Approach.Molecular imaging and biology · 2018Article
- Image-derived input function estimation on a TOF-enabled PET/MR for cerebral blood flow mapping.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Principles of Simultaneous PET/MR Imaging.Magnetic resonance imaging clinics of North America · 2017Review
- Effect of Time-of-Flight and Regularized Reconstructions on Quantitative Measurements and Qualitative Assessments in Newly Diagnosed Prostate Cancer WithMolecular imagingArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAn integrated positron emission tomography (PET)/magnetic resonance imaging (MRI) scanner with time of flight (TOF) technology is now available for clinical use. The aim of this study is to evaluate the potential of TOF PET in PET/MRI to reduce artifacts in PET images when compared to non-TOF PET/MRI, TOF PET/X-ray computed tomography (CT), and non-TOF PET/CT. PROCEDURES: All patients underwent a single 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) injection, followed first by PET/CT, and subsequently by PET/MRI. PET/CT exams were requested as standard-of-care for oncological indications. Using the PET acquisitions datasets, 4 series of images (TOF PET/CT, non-TOF PET/CT, TOF PET/MRI, and non-TOF PET/MRI) were reconstructed. These image series were visually evaluated for: (1) dental metal artifacts, (2) breathing artifacts, and (3) pelvic artifacts due to scatter correction errors from high bladder [(18)F]FDG concentration. PET image quality was assessed by a 3-point scale (1-clinically significant artifact, 2-non clinically significant artifact, and 3-no artifact).
resultsTwenty-five patients (mean ± SD age: 56 ± 13 years old; female: 10, male: 15) were enrolled. TOF PET/MRI, non-TOF PET/MRI, TOF PET/CT, and non-TOF PET/CT scores 2.8, 2.5, 2.4, and 2.3, respectively for the presence of dental artifacts, 2.8, 2.5, 2.2, and 1.9, respectively, for the presence of breathing artifacts, and 2.7, 1.7, 2.0, and 1.3, respectively, for the presence of pelvic artifacts TOF PET/MRI images showed the highest image quality scores among the 4 datasets of PET images.
conclusionThe superior timing resolution and resulting TOF capability of the new PET/MRI scanner improved PET image quality in this cohort by reducing artifacts compared to non-TOF PET/MRI, TOF PET/CT, and non-TOF PET/CT.
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