Evidence map›Paper›PMID 26883900›Full record

ArticleHerz2016

[Impact of guideline adherence on mortality in treatment of left heart failure].

S Neubauer, T Schilling, J Zeidler, A Lange, S Engel, R Linder, F Verheyen, J-M Graf von der Schulenburg, A Haverich

Abstract read
PubMed Publisher
In one paragraph

Article in Herz, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

S NeubauerLeibniz Universität Hannover, Center for Health Economics Research Hannover (CHERH), Hannover, Deutschland. sn@cherh.de.
T SchillingMedizinische Hochschule Hannover, Klinik für Herz-, Thorax-, Transplantations- und Gefäßchirurgie (HTTG), Hannover, Deutschland.
J ZeidlerLeibniz Universität Hannover, Center for Health Economics Research Hannover (CHERH), Hannover, Deutschland.
A LangeLeibniz Universität Hannover, Center for Health Economics Research Hannover (CHERH), Hannover, Deutschland.
S EngelTechniker Krankenkasse, Wissenschaftliches Institut für Nutzen und Effizienz im Gesundheitswesen (WINEG), Hamburg, Deutschland.
R LinderTechniker Krankenkasse, Wissenschaftliches Institut für Nutzen und Effizienz im Gesundheitswesen (WINEG), Hamburg, Deutschland.
F VerheyenTechniker Krankenkasse, Wissenschaftliches Institut für Nutzen und Effizienz im Gesundheitswesen (WINEG), Hamburg, Deutschland.
J-M Graf von der SchulenburgLeibniz Universität Hannover, Center for Health Economics Research Hannover (CHERH), Hannover, Deutschland.
A HaverichMedizinische Hochschule Hannover, Klinik für Herz-, Thorax-, Transplantations- und Gefäßchirurgie (HTTG), Hannover, Deutschland.
Leibniz University Hannover · DETechniker Krankenkasse (Germany) · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe German national guidelines on chronic heart failure provide treatment recommendations to physicians and reflect the current level of evidence; however, it is questionable to what extent these recommendations are applied in the routine practice and what the effect of guideline adherence on mortality is.

methodsIn this study the claims data of a major German health insurance fund collected over a period of 4 years were analyzed. Using binary logistic regression and Cox regression analyses the influence of drug prescriptions, diagnostic measures, influenza vaccination, the New York Heart Association (NYHA) status, the age and gender on mortality were examined.

resultsThe study population consisted of 85,465 heart failure patients. Approximately 60 % of the drugs were prescribed according to the guidelines. There was a positive correlation between a higher NYHA status and mortality with an odds ratio (OR) of 3.264. Especially pharmacotherapy with angiotensin-converting enzyme (ACE) inhibitors and beta blockers according to the guidelines was associated with a lower mortality rate (OR 0.448 resp. 0.444). Also patients diagnosed using echocardiography at regular intervals showed a lower risk of dying (OR 0.314).

conclusionThe results of this large sample could confirm the results of clinical trials that a therapy according to the guidelines has a significant impact on mortality. By analyzing the claims data evidence was found that in the treatment of heart failure patients the medical results could be improved by adherence to guideline recommendations.

Indexed as

Practice Guidelines as TopicAgedAged, 80 and overAge DistributionCardiologyCardiotonic AgentsEchocardiographyFemaleGermanyGuideline AdherenceHeart FailureHumansMaleMiddle AgedPrevalenceRisk FactorsCardiotonic AgentsClaims dataGuideline adherenceHeart failureMortalityPharmacotherapy

Identifiers

PMID26883900
OpenAlexW2279771332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.