ReviewNutrition reviews2016
Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota.
Review in Nutrition reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review: Role of dietary supplements on markers of exercise-associated gut damage and permeability.PloS one · 2022Pooled it
- Climate change-associated heat extremes and immune dysregulation: emerging links with autoimmunity, allergy, and infectious diseases.Seminars in immunopathology · 2026Review
- Exercise-induced intestinal barrier dysfunction: a potential contributor to athlete mental health.BMJ open sport & exercise medicine · 2026Article
- Celastrol Activates HSF1 to Enhance Regulatory T Cells Function and Ameliorate Intestinal Inflammation.Biomolecules · 2025Article
- Genomic and functional characterization of amSystems · 2025Article
- Tree Shade Improves Milking Performance, Apparent Digestibility, Antioxidant Capacity, and Immunity of Dairy Cows in Open Sheds.Animals : an open access journal from MDPI · 2025Article
- Review
- Intestinal mucosal turnover in germ-free piglets infected with E. coli.Journal of molecular histology · 2024Article
- Selection for stress tolerance and longevity in Drosophila melanogaster have strong impacts on microbiome profiles.Scientific reports · 2024Article
- The Importance of Maintaining and Improving a Healthy Gut Microbiota in Athletes as a Preventive Strategy to Improve Heat Tolerance and Acclimatization.Microorganisms · 2024Review
- Cross-species gut microbiota transplantation predictably affects host heat tolerance.The Journal of experimental biology · 2024Article
- Secreted glucose regulated protein78 ameliorates DSS-induced mouse colitis.Frontiers in immunology · 2023Article
- Profile of Serum Heat Shock Protein-27 Level in Patients with Salivary Gland Tumor.Journal of dentistry (Shiraz, Iran) · 2022Article
- Alterations in the gut microbiome and metabolic profile in rats acclimated to high environmental temperature.Microbial biotechnology · 2022Article
- The Emerging Scenario of the Gut-Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- E-waste polycyclic aromatic hydrocarbon (PAH) exposure leads to child gut-mucosal inflammation and adaptive immune response.Environmental science and pollution research international · 2021Article
- Intestinal microbiota and kidney diseases.Kidney research and clinical practice · 2021Article
- Broiler production challenges in the tropics: A review.Veterinary medicine and science · 2021Review
- Article
- Gut Microbiota ofFrontiers in microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epidemic of metabolic diseases has raised questions about the interplay between the human diet and the gut and its microbiota. The gut has two vital roles: nutrient absorption and intestinal barrier function. Gut barrier defects are involved in many diseases. Excess energy intake disturbs the gut microbiota and favors body entry of microbial compounds that stimulate chronic metabolic inflammation. In this context, the natural defense mechanisms of gut epithelial cells and the potential to boost them nutritionally warrant further study. One such important defense system is the activation of inducible heat-shock proteins (iHSPs) which protect the gut epithelium against oxidative stress and inflammation. Importantly, various microbial components can induce the expression of iHSPs. This review examines gut epithelial iHSPs as the main targets of microbial signals and nutrients and presents data on diseases involving disturbances of gut epithelial iHSPs. In addition, a broad literature analysis of dietary modulation of gut epithelial iHSPs is provided. Future research aims should include the identification of gut microbes that can optimize gut-protective iHSPs and the evaluation of iHSP-mediated health benefits of nutrients and food components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.