Evidence map›Paper›PMID 26883821›Full record

ArticleJournal of bacteriology2016

Reinterpreting Long-Term Evolution Experiments: Is Delayed Adaptation an Example of Historical Contingency or a Consequence of Intermittent Selection?

John R Roth, Sophie Maisnier-Patin

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Accelerating pathway evolution by increasing the gene dosage of chromosomal segments.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

John R RothDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, California, USA jrroth@ucdavis.edu.
Sophie Maisnier-PatinDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, California, USA.

Funding

GENETIC ANALYSIS OF BACTERIAL CHROMSOME STRUCTURER01GM027068 · NIGMS · UNIVERSITY OF UTAH · PI ROTH, JOHN R · 1985 to 2018
$8.9M
NIGMS NIH HHS GM27068NIGMS NIH HHS R01 GM027068
6 · The paper itself

Abstract

Van Hofwegen et al. demonstrated that Escherichia coli rapidly evolves the ability to use citrate when long selective periods are provided (D. J. Van Hofwegen, C. J. Hovde, and S. A. Minnich, J Bacteriol 198:1022-1034, 2016, http://dx.doi.org/10.1128/JB.00831-15). This contrasts with the extreme delay (15 years of daily transfers) seen in the long-term evolution experiments of Lenski and coworkers. Their idea of "historical contingency" may require reinterpretation. Rapid evolution seems to involve selection for duplications of the whole cit locus that are too unstable to contribute when selection is provided in short pulses.

Indexed as

Biological EvolutionSelection, GeneticCitratesDicarboxylic Acid TransportersEscherichia coli K12Escherichia coli ProteinsOrganic Anion TransportersCitratesDicarboxylic Acid TransportersEscherichia coli ProteinsOrganic Anion Transporters

Identifiers

PMID26883821
PMCPMC4800865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.