ArticleScientific reports2016
Controlled Immobilization Strategies to Probe Short Hyaluronan-Protein Interactions.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Chemical Modification of Hyaluronan and Their Biomedical Applications.Frontiers in chemistry · 2022Review
- Natural Presentation of Glycosaminoglycans in Synthetic Matrices for 3D Angiogenesis Models.Frontiers in cell and developmental biology · 2021Article
- A quartz crystal microbalance modified with antibody-coated silver nanoparticles acting as mass signal amplifiers for real-time monitoring of three latent tuberculosis infection biomarkers.Mikrochimica acta · 2019Article
- Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells.Scientific reports · 2018Article
- Multivalent and multifunctional polysaccharide-based particles for controlled receptor recognition.Scientific reports · 2018Article
- Quartz Crystal Microbalance With Dissipation Monitoring: A Powerful Method to Predict theFrontiers in bioengineering and biotechnology · 2018Review
- Tuning RGD Motif and Hyaluronan Density to Study Integrin Binding.Frontiers in physiology · 2018Article
- Effect of Co-presentation of Adhesive Ligands and Short Hyaluronan on Lymphendothelial Cells.Frontiers in bioengineering and biotechnology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Well-controlled grafting of small hyaluronan oligosaccharides (sHA) enables novel approaches to investigate biological processes such as angiogenesis, immune reactions and cancer metastasis. We develop two strategies for covalent attachment of sHA, a fast high-density adsorption and a two-layer system that allows tuning the density and mode of immobilization. We monitored the sHA adlayer formation and subsequent macromolecular interactions by label-free quartz crystal microbalance with dissipation (QCM-D). The modified surfaces are inert to unspecific protein adsorption, and yet retain the specific binding capacity of sHA. Thus they are an ideal tool to study the interactions of hyaluronan-binding proteins and short hyaluronan molecules as demonstrated by the specific recognition of LYVE-1 and aggrecan. Both hyaladherins recognize sHA and the binding is independent to the presence of the reducing end.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.