ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016
Caffeine reduces the sensitivity of vasodilator MPI for the detection of myocardial ischaemia: Pro.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Pooled it
- Adenosine-caffeine: the agonist-antagonist couple for vasodilator stress tests.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Effect of aminophylline administration on the diagnostic yield of vasodilator myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Hold off on that shot of Java: more evidence that caffeine intake leads to false negative adenosine stress myocardial perfusion.The international journal of cardiovascular imaging · 2017Article
- Caffeine does not significantly reduce the sensitivity of vasodilator stress MPI: Rebuttal.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- The judgement of the eye.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Caffeine intake and myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
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1 author at 1 institution in 1 country.
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Abstract
Caffeine is a non-selective antagonist at the adenosine receptors, which is expected to reverse both the intended (coronary vasodilation) and unintended (hypotension, flushing) effects of exogenously administered adenosine and adenosine-related compounds. In the past, several studies were conducted to characterize the effect of caffeine on vasodilator myocardial perfusion imaging (MPI) with conflicting results. However, new evidence supports earlier observations and shows that recent caffeine intake attenuates vasodilator-induced myocardial hyperaemia and may therefore reduce the sensitivity of radionuclide MPI for the detection of inducible perfusion abnormality in patients with coronary artery disease. Although the magnitude of this effect and hence its clinical significance are dose dependent, the acute response to equivalent doses of caffeine varies largely among individuals, and this might be explained by differences in caffeine exposure and genetically determined variations in caffeine metabolism. Abstinence from caffeinated foods and beverages for a minimum of 12 hours before vasodilator stress is therefore recommended although longer abstention might be required in order to prevent the potentially blocking effect of residual caffeine on vasodilator-mediated actions.
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Registered trials
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