ArticleMucosal immunology2016
T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis.
Article in Mucosal immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Characterization of intestinal immune responses in generalized human and murine lipodystrophy.The Journal of clinical investigation · 2026Article
- Targeting CD4+ T cells through gut microbiota: therapeutic potential of traditional Chinese medicine in inflammatory bowel disease.Frontiers in cellular and infection microbiology · 2025Review
- T-bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The miR-20a/miR-92b Profile Is Associated with Circulating γδ T-Cell Perturbations in Mild Psoriasis.International journal of molecular sciences · 2023Article
- CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease.International journal of molecular sciences · 2023Review
- Antigen presentation by lung epithelial cells directs CD4Nature communications · 2021Article
- Changes in γδT Cells in Peripheral Blood of Patients with Ulcerative Colitis Exacerbations.Archivum immunologiae et therapiae experimentalis · 2021Article
- Immunological memory in rheumatic inflammation - a roadblock to tolerance induction.Nature reviews. Rheumatology · 2021Review
- Murine T-Cell Transfer Colitis as a Model for Inflammatory Bowel Disease.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases.Frontiers in immunology · 2021Review
- T follicular helper cells are elevated in a rat model of autoimmune myocarditis.FEBS open bio · 2020Article
- Specific T-Cell Subsets Can Predict the Efficacy of Anti-TNF Treatment in Inflammatory Bowel Diseases.Archivum immunologiae et therapiae experimentalis · 2020Article
- TNF-α Contributes to Lymphoid Tissue Disorganization and Germinal Center B Cell Suppression during Intracellular Bacterial Infection.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- T-bet-independent Th1 response induces intestinal immunopathology during Toxoplasma gondii infection.Mucosal immunology · 2018Article
- Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo.Journal of autoimmunity · 2018Article
- CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- T-lymphocyte-derived enkephalins reduce TJournal of gastroenterology · 2018Article
- Divergent Roles of Interferon-γ and Innate Lymphoid Cells in Innate and Adaptive Immune Cell-Mediated Intestinal Inflammation.Frontiers in immunology · 2018Article
- The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice.European journal of immunology · 2018Article
- mPGES-1-Mediated Production of PGEFrontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor T-bet is highly expressed by Th cells isolated from the inflamed intestine of Crohn's disease patients, and has been regarded a critical driver of murine T cell-induced colitis. However, we show here that T-bet expression by Th cells is not required for the manifestation of T-cell-induced colitis in the presence of segmented filamentous bacteria and Helicobacter hepaticus. T-bet expression by Th cells controls their survival and localization, their repertoire of chemokine and chemokine receptor expression, the accumulation of monocytes and macrophages in the inflamed colon, and their differentiation to the M1 type, i.e., type 1 inflammation. Nevertheless, T-bet-deficient Th cells efficiently induce colitis, as reflected by weight loss, diarrhea, and colon histopathology. T-bet-deficient Th cells differentiate into Th1/17 cells, able to express IFN-γ and IL-17A upon restimulation. While neutralization of IL-17A exacerbated colitis induced by wild-type or T-bet-deficient Th cells, neutralization of IFN-γ completely abolished colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.