ArticleAntimicrobial agents and chemotherapy2016
Preventing Implant-Associated Infections by Silver Coating.
Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Microbial Biofilm Decontamination on Dental Implant Surfaces: A Mini Review.Frontiers in cellular and infection microbiology · 2021Pooled it
- Enhanced antibacterial activities of zirconia nanoparticles modified with yttrium oxide and alumina.Scientific reports · 2026Article
- Functional design of anastomotic staples in gastrointestinal surgery: mechanistic insights and clinical translation.Biomedical engineering online · 2026Review
- Functional biomaterials for the treatment of periprosthetic joint infection: A systematic review of preclinical animal studies.Journal of orthopaedic translation · 2026Review
- From adhesion to biofilms formation and resilience: Exploring the impact of silver nanoparticles-based biomaterials onBiofilm · 2025Article
- Current Strategies in the Prevention and Management of Infection in Open Fractures.Journal of orthopaedics and sports medicine · 2025Article
- Antimicrobial Effects of Metal Coatings or Physical, Chemical Modifications of Titanium Dental Implant Surfaces for Prevention of Peri-Implantitis: A Systematic Review of In Vivo Studies.Antibiotics (Basel, Switzerland) · 2024Review
- Implants coating strategies for antibacterial treatment in fracture and defect models: A systematic review of animal studies.Journal of orthopaedic translation · 2024Review
- Mechanical Properties and Corrosion Rate of ZnAg3 as a Novel Bioabsorbable Material for Osteosynthesis.Journal of functional biomaterials · 2024Article
- Use of a silver-coated plate to treat a postoperative infection after high tibial osteotomy - a case report.Journal of bone and joint infection · 2024Article
- Antibiofilm Effect of Nitric Acid-Functionalized Carbon Nanotube-Based Surfaces againstAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Deploying a Novel Approach to Prepare Silver NanoparticleAntibiotics (Basel, Switzerland) · 2023Article
- Bacterial Biofilm Formation on Biomaterials and Approaches to Its Treatment and Prevention.International journal of molecular sciences · 2023Review
- Inhibition of Cancer Cell Proliferation and Bacterial Growth by Silver(I) Complexes Bearing a CHMolecules (Basel, Switzerland) · 2023Article
- Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis.Frontiers in immunology · 2023Review
- Antibacterial and Antibiofilm Activity of Nanostructured Copper Films Prepared by Ionized Jet Deposition.Antibiotics (Basel, Switzerland) · 2022Article
- Mutagenesis and Resistance Development of Bacteria Challenged by Silver Nanoparticles.Antimicrobial agents and chemotherapy · 2022Article
- Comparative Analysis of the Mechanism of Resistance to Silver Nanoparticles and the Biocide 2,2-Dibromo-3-Nitrilopropionamide.Antimicrobial agents and chemotherapy · 2022Article
- Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review.Biomaterials research · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implant-associated infections (IAIs) are a dreaded complication mainly caused by biofilm-forming staphylococci. Implant surfaces preventing microbial colonization would be desirable. We examined the preventive effect of a silver-coated titanium-aluminum-niobium (TiAlNb) alloy. The surface elicited a strong, inoculum-dependent activity againstStaphylococcus epidermidisandStaphylococcus aureusin an agar inhibition assay. Gamma sterilization and alcohol disinfection did not alter the effect. In a tissue cage mouse model, silver coating of TiAlNb cages prevented perioperative infections in an inoculum-dependent manner and led to a 100% prevention rate after challenge with 2 × 10(6)CFU ofS. epidermidisper cage. InS. aureusinfections, silver coating had only limited effect. Similarly, daptomycin or vancomycin prophylaxis alone did not preventS. aureusinfections. However, silver coating combined with daptomycin or vancomycin prophylaxis thwarted methicillin-resistantS. aureusinfections at a prevention rate of 100% or 33%, respectively. Moreover, silver release from the surface was independent of infection and occurred rapidly after implantation. On day 2, a peak of 82 μg Ag/ml was reached in the cage fluid, corresponding to almost 6× the MIC of the staphylococci. Cytotoxicity toward leukocytes in the cage was low and temporary. Surrounding tissue did not reveal histological signs of silver toxicity.In vitro, no emergence of silver resistance was observed in several clinical strains of staphylococci upon serial subinhibitory silver exposures. In conclusion, our data demonstrate that silver-coated TiAlNb is potent for prevention of IAIs and thus can be considered for clinical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.