ArticleScientific reports2016
Serum Metabolic Profiling Reveals Altered Metabolic Pathways in Patients with Post-traumatic Cognitive Impairments.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- Urinary metabolomics data and cognitive performance in an adult population.Metabolic brain disease · 2026Article
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- Bioenergetic biomarkers as predictive indicators and their relationship with cognitive function in newly diagnosed, drug-naïve patients with bipolar disorder.Translational psychiatry · 2025Article
- Who Would Have Thought It? : Intestinal Surgery May Prove To Be the Most Effective Therapy For Traumatic Brain Injury (TBI): a Hypothesis and a Challenge.Obesity surgery · 2023Article
- Metabolomics of blood reveals age-dependent pathways in Parkinson's Disease.Cell & bioscience · 2022Article
- Temporal profile of serum metabolites and inflammation following closed head injury in rats is associated with HPA axis hyperactivity.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- A Framework to Advance Biomarker Development in the Diagnosis, Outcome Prediction, and Treatment of Traumatic Brain Injury.Journal of neurotrauma · 2022Review
- Health and cognition among adults with and without Traumatic Brain Injury: A matched case-control study.Brain injury · 2022Article
- Association of sub-acute changes in plasma amino acid levels with long-term brain pathologies in a rat model of moderate-severe traumatic brain injury.Frontiers in neuroscience · 2022Article
- Progress Toward a Multiomic Understanding of Traumatic Brain Injury: A Review.Biomarker insights · 2022Review
- Integration of Metabolomic and Clinical Data Improves the Prediction of Intensive Care Unit Length of Stay Following Major Traumatic Injury.Metabolites · 2021Article
- Alterations in Urine Metabolomics Following Sport-Related Concussion: AFrontiers in neurology · 2021Article
- Severe Spinal Cord Injury in Rats Induces Chronic Changes in the Spinal Cord and Cerebral Cortex Metabolism, Adjusted by Thiamine That Improves Locomotor Performance.Frontiers in molecular neuroscience · 2021Article
- Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache.Pain · 2020Article
- Effect of Defatted Dabai Pulp Extract in Urine Metabolomics of Hypercholesterolemic Rats.Nutrients · 2020Article
- A Pilot Study Assessing the Impact of rs174537 on Circulating Polyunsaturated Fatty Acids and the Inflammatory Response in Patients with Traumatic Brain Injury.Journal of neurotrauma · 2020Observational
- Biomarkers in traumatic brain injury: new concepts.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Using Serum Amino Acids to Predict Traumatic Brain Injury: A Systematic Approach to Utilize Multiple Biomarkers.International journal of molecular sciences · 2020Article
- Metabolomics Analysis of Hippocampus and Cortex in a Rat Model of Traumatic Brain Injury in the Subacute Phase.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive impairment, the leading cause of traumatic brain injury (TBI)-related disability, adversely affects the quality of life of TBI patients, and exacts a personal and economic cost that is difficult to quantify. The underlying pathophysiological mechanism is currently unknown, and an effective treatment of the disease has not yet been identified. This study aimed to advance our understanding of the mechanism of disease pathogenesis; thus, metabolomics based on gas chromatography/mass spectrometry (GC-MS), coupled with multivariate and univariate statistical methods were used to identify potential biomarkers and the associated metabolic pathways of post-TBI cognitive impairment. A biomarker panel consisting of nine serum metabolites (serine, pyroglutamic acid, phenylalanine, galactose, palmitic acid, arachidonic acid, linoleic acid, citric acid, and 2,3,4-trihydroxybutyrate) was identified to be able to discriminate between TBI patients with cognitive impairment, TBI patients without cognitive impairment and healthy controls. Furthermore, associations between these metabolite markers and the metabolism of amino acids, lipids and carbohydrates were identified. In conclusion, our study is the first to identify several serum metabolite markers and investigate the altered metabolic pathway that is associated with post-TBI cognitive impairment. These markers appear to be suitable for further investigation of the disease mechanisms of post-TBI cognitive impairment.
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