Evidence map›Paper›PMID 26883671›Full record

ReviewGenomics, proteomics & bioinformatics2016

Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer.

Yiwen Fang, Melissa J Fullwood

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genomics, proteomics & bioinformatics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 590 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
590citing papers in PubMed, 5 pooled it
24.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

590 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,135 citations in OpenAlex.

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530 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yiwen FangCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Melissa J FullwoodCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore; Yale-NUS Liberal Arts College, Singapore 138527, Singapore. Electronic address: melissa.fullwood@nus.edu.sg.
Agency for Science, Technology and Research · SGNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.

Indexed as

ChromatinChromatin Assembly and DisassemblyGene Expression RegulationHumansMicroRNAsNeoplasmsOligonucleotides, AntisenseRNA, Long NoncodingChromatinMicroRNAsOligonucleotides, AntisenseRNA, Long NoncodingAntisense oligonucleotidesCancerChromatinlncRNAsTranscription regulation

Identifiers

PMID26883671
PMCPMC4792843
OpenAlexW2259090596

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.