ArticleScientific reports2016
Photoacoustic monitoring of tumor and normal tissue response to radiation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 93 citations in OpenAlex.
- Early Radiation Therapy Response Assessment Using Multi-Scale Photoacoustic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Blood-mimicking dye phantoms for evaluating photoacoustic oximetry accuracy.Photoacoustics · 2026Article
- Multifunctional Upconversion Nanoparticles Transforming Photoacoustic Imaging: A Review.Nanomaterials (Basel, Switzerland) · 2025Review
- Development and performance validation of an affordable and portable high-resolution darkfield polarization-sensitive multispectral imaging microscope for the assessment of radiation dermatitis and fibrosis.Biomedical optics express · 2025Article
- Evaluations of an Early Change in Tumor Pathophysiology in Response to Radiotherapy with Oxygen Enhanced Electron Paramagnetic Resonance Imaging (OE EPRI).Molecular imaging and biology · 2024Article
- Mini review of photoacoustic clinical imaging: a noninvasive tool for disease diagnosis and treatment evaluation.Journal of biomedical optics · 2024Review
- TThe British journal of radiology · 2023Article
- Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain.Photoacoustics · 2023Article
- Noninvasive Monitoring of Radiation-Induced Salivary Gland Vascular Injury.Journal of dental research · 2023Article
- TNF Signaling Is Required for Castration-Induced Vascular Damage Preceding Prostate Cancer Regression.Cancers · 2022Article
- Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence.Cell reports · 2022Article
- Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging.Biosensors · 2022Review
- Functional photoacoustic microscopy of hemodynamics: a review.Biomedical engineering letters · 2022Review
- Noninvasive optoacoustic microangiography reveals dose and size dependency of radiation-induced deep tumor vasculature remodeling.Neoplasia (New York, N.Y.) · 2022Article
- Noninvasive optoacoustic imaging of breast tumor microvasculature in response to radiotherapy.Frontiers in physiology · 2022Article
- The Potential of Photoacoustic Imaging in Radiation Oncology.Frontiers in oncology · 2022Article
- Article
- Tunable blood oxygenation in the vascular anatomy of a semi-anthropomorphic photoacoustic breast phantom.Journal of biomedical optics · 2021Article
- Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors.Neoplasia (New York, N.Y.) · 2021Article
- Imaging methods to evaluate tumor microenvironment factors affecting nanoparticle drug delivery and antitumor response.Cancer drug resistance (Alhambra, Calif.) · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hypoxia is a recognized characteristic of tumors that influences efficacy of radiotherapy (RT). Photoacoustic imaging (PAI) is a relatively new imaging technique that exploits the optical characteristics of hemoglobin to provide information on tissue oxygenation. In the present study, PAI based measures of tumor oxygen saturation (%sO2) were compared to oxygen-enhanced magnetic resonance imaging (MRI) measurements of longitudinal relaxation rate (R1 = 1/T1) and ex-vivo histology in patient derived xenograft (PDX) models of head and neck cancer. PAI was utilized to assess early changes (24 h) in %sO2 following RT and chemoRT (CRT) and to assess changes in salivary gland hemodynamics following radiation. A significant increase in tumor %sO2 and R1 was observed following oxygen inhalation. Good spatial correlation was observed between PAI, MRI and histology. An early increase in %sO2 after RT and CRT detected by PAI was associated with significant tumor growth inhibition. Twenty four hours after RT, PAI also detected loss of hemodynamic response to gustatory stimulation in murine salivary gland tissue suggestive of radiation-induced vascular damage. Our observations illustrate the utility of PAI in detecting tumor and normal tissue hemodynamic response to radiation in head and neck cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.