ArticleInfection and immunity2016
The Yersiniabactin-Associated ATP Binding Cassette Proteins YbtP and YbtQ Enhance Escherichia coli Fitness during High-Titer Cystitis.
Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Dietary iron and metal-based growth promoters differentially modulate the gut resistome and Escherichia coli virulome in weaned pigs.Journal of animal science and biotechnology · 2026Article
- Transcriptional changes related to metabolic and iron acquisition strategies of avian pathogenicFrontiers in cellular and infection microbiology · 2026Article
- The dual implications of iron homeostasis as a bacterial threat: its roles in virulence and antimicrobial resistance.Archives of microbiology · 2025Review
- Evolution of pathogenic Escherichia coli harboring the transmissible locus of stress tolerance: from food sources to clinical environments.Scientific reports · 2025Article
- Genomic Characterization of Multidrug-Resistant Enterobacteriaceae Clinical Isolates from Southern Thailand Hospitals: Unraveling Antimicrobial Resistance and Virulence Mechanisms.Antibiotics (Basel, Switzerland) · 2024Article
- Mechanistic Insights Revealed by YbtPQ in the Occluded State.Biomolecules · 2024Article
- Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone.Nature communications · 2024Article
- Analysis of the hypovirulentMicrobiology spectrum · 2024Article
- Genome-wide identification of genes critical forVirulence · 2023Article
- ThemBio · 2022Article
- Copper Homeostatic Mechanisms and Their Role in the Virulence of Escherichia coli and Salmonella enterica.EcoSal Plus · 2021Review
- Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics.Chemical reviews · 2021Review
- Transcriptional Profiling of the ProbioticInternational journal of molecular sciences · 2020Article
- Pathogenic siderophore ABC importer YbtPQ adopts a surprising fold of exporter.Science advances · 2020Article
- Uropathogenic enterobacteria use the yersiniabactin metallophore system to acquire nickel.The Journal of biological chemistry · 2018Article
- The iron hand of uropathogenic Escherichia coli: the role of transition metal control in virulence.Future microbiology · 2018Review
- Enterobacteria secrete an inhibitor of Pseudomonas virulence during clinical bacteriuria.The Journal of clinical investigation · 2017Article
- Copper import in Escherichia coli by the yersiniabactin metallophore system.Nature chemical biology · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Yersinia high-pathogenicity island (HPI) is common to multiple virulence strategies used by Escherichia coli strains associated with urinary tract infection (UTI). Among the genes in this island are ybtP and ybtQ, encoding distinctive ATP binding cassette (ABC) proteins associated with iron(III)-yersiniabactin import in Yersinia pestis In this study, we compared the impact of ybtPQ on a model E. coli cystitis strain during in vitro culture and experimental murine infections. A ybtPQ-null mutant exhibited no growth defect under standard culture conditions, consistent with nonessentiality in this background. A growth defect phenotype was observed and genetically complemented in vitro during iron(III)-yersiniabactin-dependent growth. Following inoculation into the bladders of C3H/HEN and C3H/HeOuJ mice, this strain exhibited a profound, 10(6)-fold competitive infection defect in the subgroup of mice that progressed to high-titer bladder infections. These results identify a virulence role for YbtPQ in the highly inflammatory microenvironment characteristic of high-titer cystitis. The profound competitive defect may relate to the apparent selection of Yersinia HPI-positive E. coli in uncomplicated clinical UTIs.
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