ArticleJournal of exposure science & environmental epidemiology2016
Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects.
Article in Journal of exposure science & environmental epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Long-term exposure to particulate matter on cardiovascular and respiratory diseases in low- and middle-income countries: A systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Association between maternal exposure to pollutant particulate matter 2.5 and congenital heart defects: a systematic review.JBI database of systematic reviews and implementation reports · 2019Pooled it
- Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies.International journal of epidemiology · 2019Pooled it
- Meta-Prediction of MTHFR Gene Polymorphism and Air Pollution on the Risks of Congenital Heart Defects Worldwide: A Transgenerational Analysis.International journal of environmental research and public health · 2018Pooled it
- A behavioral strategy to minimize air pollution exposure in pregnant women: a randomized controlled trial.Environmental health and preventive medicine · 2017Trial
- Maternal Exposure to Air Pollution During Early Pregnancy and Congenital Heart Disease: An Exploratory Case-Control Analysis from Delhi NCR.Indian journal of pediatrics · 2026Article
- A Mechanistic Review of Environmental Stressor to Decode Their Effect on Congenital Malformations: A Developmental Toxicity.Journal of biochemical and molecular toxicology · 2026Review
- The impact of PMScientific reports · 2026Article
- The trends of congenital heart defects burden in BRICS-plus from 1990 to 2021 and its projection to 2035.BMC pregnancy and childbirth · 2026Observational
- Review
- Congenital heart diseases: population-based cross-sectional study and spatial analysis, São Paulo, 2012-2022.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2026Article
- Industrial air pollution and newborn hearing screening failure.Journal of hazardous materials · 2025Article
- Pharmacists' knowledge, attitudes, and practices toward preventing congenital disabilities: a cross sectional study in Saudi Arabia.BMC health services research · 2025Article
- Congenital heart diseases - the forgotten country cousins?Indian journal of thoracic and cardiovascular surgery · 2025Article
- The influence of socioeconomic status on the association between residential greenness and gestational diabetes mellitus in an urban setting: a multicenter study.BMC public health · 2025Article
- From Lineage to Longevity: A Field Guide to the Key Players in Epigenetic Contribution to Offspring Health.Current issues in molecular biology · 2025Review
- Association of Maternal Exposure to Fine Particulate Matter During Pregnancy with Anterior Segment Dysgenesis Risk: A Matched Case-Control Study.Journal of clinical medicine · 2025Article
- Racial disparities in maternal exposure to ambient air pollution during pregnancy and prevalence of congenital heart defects.American journal of epidemiology · 2025Article
- Evidence of the correlation between air pollution and different types of birth defects: based on a distribution-lag non-linear model.Frontiers in public health · 2025Article
- Associations between weekly maternal exposure to ambient particulate matter and congenital heart disease.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Maternal exposure to ambient air pollution has increasingly been linked to congenital heart defects (CHDs). The objective of this study was to evaluate whether high levels of maternal exposure to PM2.5 and PM10 are related to increased risk of CHDs in Wuhan, China. We conducted a cohort study with a total of 105,988 live-born infants, stillbirths, and fetal deaths. The study included mothers living in the urban district of Wuhan during pregnancy over the 2-year period from 10 June 2011 to 9 June 2013. For each study participant, we assigned 1-month and 1-week averages of PM10 and PM2.5 exposure based on measurements obtained from the nearest exposure monitor to the living residence of mothers during their early pregnancy period. Logistic regression analyses were conducted to calculate the adjusted odds ratios (aORs) and 95% confidence intervals (CI) for the association between exposure to these ambient air pollutants during early pregnancy and CHDs. We observed an increased risk of CHDs, particularly ventricular septal defect (VSD), with increasing PM2.5 exposure. Using 1-week averages, we also observed significant monotonically increasing associations between PM2.5 exposure during weeks 7-10 of pregnancy and risk of VSD, with aORs ranging from 1.11 to 1.17 (95% CI: 1.02-1.20, 1.03-1.22, 1.05-1.24, and 1.08-1.26 separately) per a 10 μg/m(3) change in PM2.5 concentration. Our study contributes to the small body of knowledge regarding the association between in utero exposure to air pollution and CHDs, but confirmation of these associations will be needed in future studies.
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