ArticleScientific reports2016
A simple method for the production of large volume 3D macroporous hydrogels for advanced biotechnological, medical and environmental applications.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Nanoparticle-Hydrogel Composites for Precision Medicine.Cell biomaterials · 2026Article
- Cryogel-based therapeutic platforms for disease modification in osteoarthritis.npj biomedical innovations · 2026Review
- CFD Mechanistic Modeling of a Monolithic Chromatography System: Challenges and Opportunities.ACS omega · 2026Review
- Amino Acid-Based Hydrophobic Cryogels for Efficient Methylene Blue Removal: A Reusable and Eco-Friendly Approach to Dye-Contaminated Wastewater Treatment.Gels (Basel, Switzerland) · 2025Article
- Preparation of Polymyxin B-Functionalized Cryogels for Efficient Endotoxin Removal from Protein Solutions.Gels (Basel, Switzerland) · 2025Article
- Nanoremediation of tilapia fish culture using iron oxide nanoparticles biosynthesized by Bacillus subtilis and immobilized in a free-floating macroporous cryogel.BMC veterinary research · 2024Article
- Synthesis of Poly(GG-ACS omega · 2024Article
- Exploring the Formulation and Approaches of Injectable Hydrogels Utilizing Hyaluronic Acid in Biomedical Uses.Advances in pharmacological and pharmaceutical sciences · 2024Review
- Strategy Based on Michael Addition Reaction for the Development of Bioinspired Multilayered and Multiphasic 3D Constructs.Polymers · 2023Article
- Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells.Nature biotechnology · 2022Article
- Shrinkable Hydrogel-Enhanced Biomarker Detection with X-ray Fluorescent Nanoparticles.Nanomaterials (Basel, Switzerland) · 2022Article
- Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations.Pharmaceutics · 2022Review
- Translational Applications of Hydrogels.Chemical reviews · 2021Review
- Design and Assessment of Biodegradable Macroporous Cryogels as Advanced Tissue Engineering and Drug Carrying Materials.Gels (Basel, Switzerland) · 2021Review
- Injectable Cryogels in Biomedicine.Gels (Basel, Switzerland) · 2021Review
- Polymeric Materials Used for Immobilisation of Bacteria for the Bioremediation of Contaminants in Water.Polymers · 2021Review
- Lyophilized Polyvinylpyrrolidone Hydrogel for Culture of Human Oral Mucosa Stem Cells.Materials (Basel, Switzerland) · 2021Article
- Rapid Separation of Human Hemoglobin on a Large Scale From Non-clarified Bacterial Cell Homogenates Using Molecularly Imprinted Composite Cryogels.Frontiers in bioengineering and biotechnology · 2021Article
- Contactless Thermometry by MRI and MRS: Advanced Methods for Thermotherapy and Biomaterials.iScience · 2020Review
- Material-Dependent Formation and Degradation of Bone Matrix-Comparison of Two Cryogels.Bioengineering (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of bulk, three-dimensional (3D), macroporous polymers with high permeability, large surface area and large volume is highly desirable for a range of applications in the biomedical, biotechnological and environmental areas. The experimental techniques currently used are limited to the production of small size and volume cryogel material. In this work we propose a novel, versatile, simple and reproducible method for the synthesis of large volume porous polymer hydrogels by cryogelation. By controlling the freezing process of the reagent/polymer solution, large-scale 3D macroporous gels with wide interconnected pores (up to 200 μm in diameter) and large accessible surface area have been synthesized. For the first time, macroporous gels (of up to 400 ml bulk volume) with controlled porous structure were manufactured, with potential for scale up to much larger gel dimensions. This method can be used for production of novel 3D multi-component macroporous composite materials with a uniform distribution of embedded particles. The proposed method provides better control of freezing conditions and thus overcomes existing drawbacks limiting production of large gel-based devices and matrices. The proposed method could serve as a new design concept for functional 3D macroporous gels and composites preparation for biomedical, biotechnological and environmental applications.
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Registered trials
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