ArticleMolecular and cellular pediatrics2016
Underlying molecular and cellular mechanisms in childhood irritable bowel syndrome.
Article in Molecular and cellular pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Effects of probiotic supplementation on abdominal pain severity in pediatric patients with irritable bowel syndrome: a systematic review and meta-analysis of randomized clinical trials.World journal of pediatrics : WJP · 2022Pooled it
- Fructan-sensitive children with irritable bowel syndrome have distinct gut microbiome signatures.Alimentary pharmacology & therapeutics · 2021Trial
- Targeted antibiotic and dietary approaches in managing small intestinal bacterial overgrowth across irritable bowel syndrome subtypes.Internal and emergency medicine · 2026Review
- The low FODMAP diet in adolescents functional abdominal in a non-guided setting: a prospective multicenter cohort study.European journal of pediatrics · 2025Article
- Functional Gastrointestinal Disorders and Childhood Obesity: The Role of Diet and Its Impact on Microbiota.Nutrients · 2024Review
- The prevalence and risk factors of irritable bowel syndrome (PRIBS study) among adults in low- and middle-income countries: A multicenter cross-sectional study.Health science reports · 2023Article
- Perspective: Assessing Tolerance to Nondigestible Carbohydrate Consumption.Advances in nutrition (Bethesda, Md.) · 2022Article
- LMWP (S3-3) from the Larvae ofMolecules (Basel, Switzerland) · 2022Article
- The relationship between mucosal inflammatory cells, specific symptoms, and psychological functioning in youth with irritable bowel syndrome.Scientific reports · 2020Article
- Cholesterol-Lowering Effects of Lactobacillus Species.Current microbiology · 2020Review
- Irritable Bowel Syndrome between Molecular Approach and Clinical Expertise-Searching for Gap Fillers in the Oxidative Stress Way of Thinking.Medicina (Kaunas, Lithuania) · 2020Review
- Article
- 'Rapid transit' constipation in children: a possible genesis for irritable bowel syndrome.Pediatric surgery international · 2020Review
- Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome.The Journal of molecular diagnostics : JMD · 2019Article
- Update on Dietary Management of Childhood Functional Abdominal Pain Disorders.Gastroenterology clinics of North America · 2018Review
- Evaluation of FODMAP Carbohydrates Content in Selected Foods in the United States.The Journal of pediatrics · 2018Article
- The Role of Bacteria, Probiotics and Diet in Irritable Bowel Syndrome.Foods (Basel, Switzerland) · 2018Review
- Tong-Xie-Yao-Fang Regulates 5-HT Level in Diarrhea Predominant Irritable Bowel Syndrome Through Gut Microbiota Modulation.Frontiers in pharmacology · 2018Article
- Treatment of Chronic Atopy and Irritable Bowel Syndrome in a 7-year-old: A Case Report.Integrative medicine (Encinitas, Calif.) · 2017Article
- Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex.Journal of neurogastroenterology and motility · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Irritable bowel syndrome (IBS) affects a large number of children throughout the world. The symptom expression of IBS is heterogeneous, and several factors which may be interrelated within the IBS biopsychosocial model play a role. These factors include visceral hyperalgesia, intestinal permeability, gut microbiota, psychosocial distress, gut inflammation, bile acids, food intolerance, colonic bacterial fermentation, and genetics. The molecular and cellular mechanisms of these factors are being actively investigated. In this mini-review, we present updates of these mechanisms and, where possible, relate the findings to childhood IBS. Mechanistic elucidation may lead to the identification of biomarkers as well as personalized childhood IBS therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.