SynthesisEuropean radiology2016
A meta-analysis of diffusion-weighted and gadoxetic acid-enhanced MR imaging for the detection of liver metastases.
Synthesis in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06753903 (Role of Photon Counting CT in Detecting Liver Metastatis From Colorectal Cancer), which is not on this map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Photon Counting CT in Detecting Liver Metastatis From Colorectal Cancer
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Diagnostic performance of magnetic resonance imaging for colorectal liver metastasis: A systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Detection of liver metastases on gadobenate dimeglumine-enhanced MRI: systematic review, meta-analysis, and similarities with gadoxetate-enhanced MRI.European radiology · 2019Pooled it
- MRI for restaging pancreatic cancer.Insights into imaging · 2026Article
- Intra-individual comparison of abbreviated gadoxetic acid-enhanced MRI and contrast-enhanced CT for postoperative surveillance of colorectal liver metastases: a multicenter prospective study.Abdominal radiology (New York) · 2026Article
- Enhanced diagnostic performance of WE-SHARP-DWI compared with SPAIR-DWI for focal liver lesion evaluation at 3T.Abdominal radiology (New York) · 2026Article
- Free-breathing phase-sensitive inversion recovery TMagnetic resonance in medicine · 2026Article
- Evidence for imaging-based diagnosis of liver metastases from colorectal cancer.Journal of gastroenterology · 2025Review
- Enhancing Rectal Cancer Staging: Integrating Abbreviated Liver MRI into Standard Rectal MRI Protocols for Improved Diagnostic Utility.Journal of the Korean Society of Radiology · 2025Article
- Gadoxetic acid-enhanced magnetic resonance imaging to predict pathologic complete response of colorectal liver metastases in preoperative chemotherapy.Scientific reports · 2025Article
- Comparison of abbreviated and complete MRI protocols for treatment response assessment of colorectal liver metastases.European radiology · 2025Article
- Relevance of lesion size in navigator-triggered and free-breathing diffusion-weighted liver MRI.European radiology · 2025Article
- Diagnostic performance of contrast-enhanced CT combined with contrast-enhanced MRI for colorectal liver metastases: a case-control study.BMC gastroenterology · 2025Article
- Added Value of Whole-Body Diffusion-Weighted Imaging in Patients Undergoing Prostate-Specific Membrane Antigen Positron Emission Tomography.Journal of clinical medicine · 2025Article
- MRI radiomics model differentiates small hepatic metastases and abscesses in periampullary cancer patients.Scientific reports · 2024Article
- Diffusion weighted imaging combining respiratory triggering and navigator echo tracking in the upper abdomen.Magma (New York, N.Y.) · 2024Article
- Imaging in the era of risk-adapted treatment in colon cancer.The British journal of radiology · 2024Review
- CT and MRI of abdominal cancers: current trends and perspectives in the era of radiomics and artificial intelligence.Japanese journal of radiology · 2024Review
- Added Value of Liver MRI in Patients Eligible for Surgical Resection or Ablation of Colorectal Liver Metastases Based on CT: A Systematic Review and Meta-Analysis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Yes, you should do a magnetic resonance imaging (MRI) for patients scheduled for local therapy of colorectal cancer liver metastases: insights into the CAMINO study.Translational gastroenterology and hepatology · 2024Article
- Liver metastases: The role of magnetic resonance imaging.World journal of gastroenterology · 2023Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo obtain the diagnostic performance of diffusion-weighted (DW) and gadoxetic-enhanced magnetic resonance (MR) imaging in the detection of liver metastases.
methodsA comprehensive search (EMBASE, PubMed, Cochrane) was performed to identify relevant articles up to June 2015. Inclusion criteria were: liver metastases, DW-MR imaging and/or gadoxetic acid-enhanced MR imaging, and per-lesion statistics. The reference standard was histopathology, intraoperative observation and/or follow-up. Sources of bias were assessed using the QUADAS-2 tool. A linear mixed-effect regression model was used to obtain sensitivity estimates.
resultsThirty-nine articles were included (1,989 patients, 3,854 metastases). Sensitivity estimates for DW-MR imaging, gadoxetic acid-enhanced MR imaging and the combined sequence for detecting liver metastases on a per-lesion basis was 87.1 %, 90.6 % and 95.5 %, respectively. Sensitivity estimates by gadoxetic acid-enhanced MR imaging and the combined sequence were significantly better than DW-MR imaging (p = 0.0001 and p < 0.0001, respectively), and the combined MR sequence was significantly more sensitive than gadoxetic acid-enhanced MR imaging (p < 0.0001). Similar results were observed in articles that compared the three techniques simultaneously, with only colorectal liver metastases and in liver metastases smaller than 1 cm.
conclusionsIn patients with liver metastases, combined DW-MR and gadoxetic acid-enhanced MR imaging has the highest sensitivity for detecting liver metastases on a per-lesion basis. KEY POINTS: • DW-MRI is less sensitive than gadoxetic acid-enhanced MRI for detecting liver metastases • DW-MRI and gadoxetic acid-enhanced MRI is the best combination • Same results are observed in colorectal liver metastases • Same results are observed in liver metastases smaller than 1 cm • Same results are observed when histopathology alone is the reference standard.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.