Evidence map›Paper›PMID 26883319›Full record

ArticleJournal of psychiatry & neuroscience : JPN2016

Proactive response inhibition abnormalities in the sensorimotor cortex of patients with schizophrenia.

Andrew R Mayer, Faith M Hanlon, Andrew B Dodd, Ronald A Yeo, Kathleen Y Haaland, Josef M Ling, Sephira G Ryman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  4. Evidence for asymmetric inhibitory activity during motor planning phases of sensorimotor synchronization.Cortex; a journal devoted to the study of the nervous system and behavior · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew R MayerFrom the Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM (Mayer, Hanlon, Dodd, Ling, Ryman); the Neurology Department, University of New Mexico School of Medicine, Albuquerque, NM (Mayer, Haaland); the Psychology Department, University of New Mexico, Albuquerque, NM (Mayer, Yeo, Ryman); the Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM (Haaland).
Faith M HanlonFrom the Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM (Mayer, Hanlon, Dodd, Ling, Ryman); the Neurology Department, University of New Mexico School of Medicine, Albuquerque, NM (Mayer, Haaland); the Psychology Department, University of New Mexico, Albuquerque, NM (Mayer, Yeo, Ryman); the Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM (Haaland).
Andrew B DoddFrom the Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM (Mayer, Hanlon, Dodd, Ling, Ryman); the Neurology Department, University of New Mexico School of Medicine, Albuquerque, NM (Mayer, Haaland); the Psychology Department, University of New Mexico, Albuquerque, NM (Mayer, Yeo, Ryman); the Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM (Haaland).
Ronald A YeoFrom the Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM (Mayer, Hanlon, Dodd, Ling, Ryman); the Neurology Department, University of New Mexico School of Medicine, Albuquerque, NM (Mayer, Haaland); the Psychology Department, University of New Mexico, Albuquerque, NM (Mayer, Yeo, Ryman); the Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM (Haaland).
Kathleen Y HaalandFrom the Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM (Mayer, Hanlon, Dodd, Ling, Ryman); the Neurology Department, University of New Mexico School of Medicine, Albuquerque, NM (Mayer, Haaland); the Psychology Department, University of New Mexico, Albuquerque, NM (Mayer, Yeo, Ryman); the Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM (Haaland).
Josef M LingFrom the Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM (Mayer, Hanlon, Dodd, Ling, Ryman); the Neurology Department, University of New Mexico School of Medicine, Albuquerque, NM (Mayer, Haaland); the Psychology Department, University of New Mexico, Albuquerque, NM (Mayer, Yeo, Ryman); the Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM (Haaland).
Sephira G RymanFrom the Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM (Mayer, Hanlon, Dodd, Ling, Ryman); the Neurology Department, University of New Mexico School of Medicine, Albuquerque, NM (Mayer, Haaland); the Psychology Department, University of New Mexico, Albuquerque, NM (Mayer, Yeo, Ryman); the Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM (Haaland).
Mind Research Network · USUniversity of New Mexico · US

Funding

Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI ABBOTT, CHRISTOPHER C · 2012 to 2017
$14.3M
A Multidimensional Investigation of Cognitive Control Deficits in PsychopathologyR01MH101512 · NIMH · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2014 to 2017
$2.8M
NIGMS NIH HHS P20 GM103472NIMH NIH HHS R01 MH101512
6 · The paper itself

Abstract

backgroundPrevious studies of response inhibition in patients with schizophrenia have focused on reactive inhibition tasks (e.g., stop-signal, go/no-go), primarily observing lateral prefrontal cortex abnormalities. However, recent studies suggest that purposeful and sustained (i.e., proactive) inhibition may also be affected in these patients.

methodsPatients with chronic schizophrenia and healthy controls underwent fMRI while inhibiting motor responses during multisensory (audiovisual) stimulation. Resting state data were also collected.

resultsWe included 37 patients with schizophrenia and 37 healthy controls in our study. Both controls and patients with schizophrenia successfully inhibited the majority of overt motor responses. Functional results indicated basic inhibitory failure in the lateral premotor and sensorimotor cortex, with opposing patterns of positive (schizophrenia) versus negative (control) activation. Abnormal activity was associated with independently assessed signs of psychomotor retardation. Patients with schizophrenia also exhibited unique activation of the pre-supplementary motor area (pre-SMA)/SMA and precuneus relative to baseline as well as a failure to deactivate anterior nodes of the default mode network. Independent resting-state connectivity analysis indicated reduced connectivity between anterior (task results) and posterior regions of the sensorimotor cortex for patients as well as abnormal connectivity between other regions (cerebellum, thalamus, posterior cingulate gyrus and visual cortex). LIMITATIONS: Aside from rates of false-positive responses, true proactive response inhibition tasks do not provide behavioural metrics that can be independently used to quantify task performance.

conclusionOur results suggest that basic cortico-cortico and intracortical connections between the sensorimotor cortex and adjoining regions are impaired in patients with schizophrenia and that these impaired connections contribute to inhibitory failures (i.e., a positive rather than negative hemodynamic response).

Indexed as

Proactive InhibitionAdultAuditory PerceptionBrain MappingChronic DiseaseFemaleHumansMagnetic Resonance ImagingMaleMotor ActivityNeural PathwaysNeuropsychological TestsRestSchizophreniaSchizophrenic PsychologySensorimotor Cortex

Identifiers

PMID26883319
PMCPMC5008920
OpenAlexW2432624844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.