ArticleScientific reports2016
Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- The effect of four weeks blood flow restricted resistance training on macro- and micro-vascular function in healthy, young men.European journal of applied physiology · 2023Trial
- Review
- Recent progress in unraveling cardiovascular complications associated with primary aldosteronism: a succinct review.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Synergistic effect of albuminuria on atherosclerosis in patients with primary aldosteronism.Therapeutic advances in chronic disease · 2023Article
- Mineralocorticoid receptor antagonist treatment improved arterial stiffness in patients with primary aldosteronism: a cohort study compared with adrenalectomy.Therapeutic advances in chronic disease · 2023Article
- 2022 Guidelines of the Taiwan Society of Cardiology and the Taiwan Hypertension Society for the Management of Hypertension.Acta Cardiologica Sinica · 2022Article
- KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma.Frontiers in endocrinology · 2022Article
- Diabetes mellitus is associated with worse baseline and less post-treatment recovery of arterial stiffness in patients with primary aldosteronism.Therapeutic advances in chronic disease · 2022Article
- Heart-Ankle Pulse Wave Velocity Is Superior to Brachial-Ankle Pulse Wave Velocity in Detecting Aldosterone-Induced Arterial Stiffness.Biomedicines · 2021Article
- Left ventricular remodeling and dysfunction in primary aldosteronism.Journal of human hypertension · 2021Review
- Aldosterone-to-renin ratio is related to arterial stiffness when the screening criteria of primary aldosteronism are not met.Scientific reports · 2020Article
- Restoring Blood Pressure in Hypertensive Mice Fails to Fully Reverse Vascular Stiffness.Frontiers in physiology · 2020Article
- Endothelial Dysfunction in Primary Aldosteronism.International journal of molecular sciences · 2019Review
- Maintenance of long-term blood pressure control and vascular health by low-dose amiloride-based therapy in hyperaldosteronism.Journal of clinical hypertension (Greenwich, Conn.) · 2019Observational
- Long-term BP control and vascular health in patients with hyperaldosteronism treated with low-dose, amiloride-based therapy.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Primary Aldosteronism and Cerebrovascular Diseases.Endocrinology and metabolism (Seoul, Korea) · 2018Review
- Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness.Hypertension (Dallas, Tex. : 1979) · 2018Review
- Potential Role of Antihypertensive Medications in Preventing Excessive Arterial Stiffening.Current hypertension reports · 2018Review
- Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy.Oncotarget · 2017Article
- Dual benefits of renin-angiotensin-aldosterone blockade: lowering the blood pressure and de-stiffening the arteries.Journal of thoracic disease · 2016Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary aldosteronism not only results in hypertension but also stiffer arteries. The time course and factors predicting the reversal of arterial stiffness after treatment are unclear. We prospectively enrolled 102 patients with aldosterone-producing adenoma (APA) from March 2006 to January 2012. We measured the pulse wave velocity (PWV) between brachial-ankle (baPWV) and heart-ankle (haPWV) before, 6 and 12 months after their adrenalectomy. After treatment, the PWV decreased significantly during the first 6 months (both p < 0.001), but no further reduction in the following 6 months. The determinant factors for baseline baPWV were age, duration of hypertension, and baseline systolic blood pressure (SBP) in multivariate linear regression analysis, similar with baseline haPWV (determinants: age, duration of hypertension, baseline SBP and diastolic blood pressure (DBP)). In multivariate linear regression analysis, the decrease in DBP at 6 months (ΔDBP0-6mo) and baseline baPWV were significantly associated with the decrease in baPWV at 6 months (ΔbaPWV0-6mo). The associated factors of the change in haPWV at 6 months (ΔhaPWV0-6mo) were baseline haPWV, ΔDBP0-6mo and change in log-transformed plasma renin activity. Our result suggested that reversal of arterial stiffness in APA patients occurred early after adrenalectomy and determined by baseline vascular condition, hemodynamic factors, and humoral factors.
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