ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2016
Copy number variation of CBF-A14 at the Fr-A2 locus determines frost tolerance in winter durum wheat.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 74 citations in OpenAlex.
- Optimizing wheat development to a range of winter climates.Journal of experimental botany · 2026Review
- Article
- From Shared Mechanisms to Precision Breeding: Engineering Cold and Drought Cross-Tolerance in Crops.International journal of molecular sciences · 2026Review
- Predictive breeding and marker-assisted selection for grain quality and freezing tolerance in durum wheat.Frontiers in plant science · 2026Article
- Genetic Dissection of Frost Tolerance in Winter Durum Wheat: Three Validated KASP Markers for Marker-Assisted Selection.Plants (Basel, Switzerland) · 2025Article
- Structural Variants Contribute to Phenotypic Variation in Maize.Molecular ecology · 2025Article
- Genome-wide association analysis of winter survival in a diverse Canadian winter wheat population.The plant genome · 2025Article
- Effect of geographical origin, regional adaptation, genotype, and release year on winter hardiness of wheat and triticale accessions evaluated for six decades in trials.Scientific reports · 2025Article
- Article
- Structural variants contribute to phenotypic variation in maize.bioRxiv : the preprint server for biology · 2024Article
- Low frequency of the wild-type freezing-tolerance LsCBF7 allele among lettuce population suggests a negative selection during domestication and breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genomic insights into the origin and evolution of spelt (Triticum spelta L.) as a valuable gene pool for modern wheat breeding.Plant communications · 2024Article
- KASP: a high-throughput genotyping system and its applications in major crop plants for biotic and abiotic stress tolerance.Molecular biology reports · 2024Review
- Evolutionary and synteny analysis of HIS1, BADH2, GBSS1, and GBSS2 in rice: insights for effective introgression breeding strategies.Scientific reports · 2024Article
- Identification of genetic loci and candidate genes underlying freezing tolerance in wheat seedlings.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- TheCells · 2023Review
- Molecular and genetic perspectives of cold tolerance in wheat.Molecular biology reports · 2023Review
- Chromosome diversity in Dasypyrum villosum, an important genetic and trait resource for hexaploid wheat engineering.Annals of botany · 2023Article
- Physiology and Molecular Breeding in Sustaining Wheat Grain Setting and Quality under Spring Cold Stress.International journal of molecular sciences · 2022Review
- Transcription-associated metabolomic profiling reveals the critical role of frost tolerance in wheat.BMC plant biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageFrost tolerance in durum wheat is mainly controlled by copy number variation of CBF - A14 at the Fr - A2 locus. Frost tolerance is a key trait for successful breeding of winter durum wheat (Triticum durum) which can increase the yield performance in regions favoring autumn-sown winter cereals. The aim of this study was to investigate the genetic architecture of frost tolerance in order to provide molecular support for the breeding of winter durum wheat. To this end, a diverse panel of 170 winter and 14 spring durum wheat genotypes of worldwide origin was evaluated for frost tolerance in the field, as well as in a semi-controlled test. A total of 30,611 polymorphic genome-wide markers obtained by a genotyping-by-sequencing approach and markers for candidate loci were used to assess marker-trait associations. One major QTL was detected on chromosome 5A, likely corresponding to Frost Resistance-A2 (Fr-A2). Further analyses strongly support the conclusion that copy number variation of CBF-A14 at the Fr-A2 locus is the causal polymorphism underlying this major QTL. It explains 91.6 % of the genotypic variance and a haploblock of two strongly associated markers in the QTL region also allowed to capture the variance of this QTL. In addition to this major QTL, a much smaller contribution of 4.2 % was observed for Fr-B2. We further investigated this major QTL and found that the copy number of CBF-A14 and the frequency of the frost tolerant haplotype mirrored the climatic conditions in the genotypes' country of origin, suggesting selection through breeding. Two functional KASP markers were developed which facilitate a high-throughput screening of the haploblock and thus a marker-based breeding of frost tolerance in winter durum wheat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.