ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2016
Outlier detection methods for generalized lattices: a case study on the transition from ANOVA to REML.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65 citing papers in PubMed.
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- Integrating genomic predictions into an applied Central European wheat breeding program.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
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- Genetic Variation and Quantitative Trait Loci Analysis of the Maize Ionome in Response to Phosphorus Fertilisation.Plant, cell & environment · 2025Article
- Powerful one-dimensional scan to detect heterotic quantitative trait loci.Nature communications · 2025Article
- Harnessing historical genebank data to accelerate pea breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Harnessing big data for enhanced genome-wide prediction in winter wheat breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Breaking down data silos across companies to train genome-wide predictions: A feasibility study in wheat.Plant biotechnology journal · 2025Article
- Genetic Dissection of Drought Tolerance in Maize Through GWAS of Agronomic Traits, Stress Tolerance Indices, and Phenotypic Plasticity.International journal of molecular sciences · 2025Article
- Integrative multi-environmental genomic prediction in apple.Horticulture research · 2025Article
- Evaluation of genomic and phenomic prediction for application in apple breeding.BMC plant biology · 2025Article
- Combining ability and heterosis analysis for mineral content in the leafy vegetable Gynandropsis gynandra (L.) Briq.PloS one · 2025Article
- Mapping rust resistance in European winter wheat: many QTLs for yellow rust resistance, but only a few well characterized genes for stem rust resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genetic association analysis in sugarcane (Saccharum spp.) for sucrose accumulation in humid environments in Colombia.BMC plant biology · 2024Article
- Implementation of theoretical non-photochemical quenching (NPQScientific reports · 2024Article
5 more citing papers are in PubMed but not listed here.
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Abstract
key messageWe review and propose several methods for identifying possible outliers and evaluate their properties. The methods are applied to a genomic prediction program in hybrid rye. Many plant breeders use ANOVA-based software for routine analysis of field trials. These programs may offer specific in-built options for residual analysis that are lacking in current REML software. With the advance of molecular technologies, there is a need to switch to REML-based approaches, but without losing the good features of outlier detection methods that have proven useful in the past. Our aims were to compare the variance component estimates between ANOVA and REML approaches, to scrutinize the outlier detection method of the ANOVA-based package PlabStat and to propose and evaluate alternative procedures for outlier detection. We compared the outputs produced using ANOVA and REML approaches of four published datasets of generalized lattice designs. Five outlier detection methods are explained step by step. Their performance was evaluated by measuring the true positive rate and the false positive rate in a dataset with artificial outliers simulated in several scenarios. An implementation of genomic prediction using an empirical rye multi-environment trial was used to assess the outlier detection methods with respect to the predictive abilities of a mixed model for each method. We provide a detailed explanation of how the PlabStat outlier detection methodology can be translated to REML-based software together with the evaluation of alternative methods to identify outliers. The method combining the Bonferroni-Holm test to judge each residual and the residual standardization strategy of PlabStat exhibited good ability to detect outliers in small and large datasets and under a genomic prediction application. We recommend the use of outlier detection methods as a decision support in the routine data analyses of plant breeding experiments.
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