ArticleVision research2016
Maintaining ocular safety with light exposure, focusing on devices for optogenetic stimulation.
Article in Vision research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- RGB Color-Discriminable Photonic Synapse for Neuromorphic Vision System.Nano-micro letters · 2024Article
- Theoretical prediction of broadband ambient light optogenetic vision restoration with ChRmine and its mutants.Scientific reports · 2024Article
- Light-enhanced molecular polarity enabling multispectral color-cognitive memristor for neuromorphic visual system.Nature communications · 2023Article
- A clinically viable approach to restoring visual function using optogenetic gene therapy.Molecular therapy. Methods & clinical development · 2023Article
- Compact and ultracompact spectral imagers: technology and applications in biomedical imaging.Journal of biomedical optics · 2023Review
- An Engineering Platform for Clinical Application of Optogenetic Therapy in Retinal Degenerative Diseases.IEEE journal of translational engineering in health and medicine · 2023Article
- Optoelectronic Neural Interfaces Based on Quantum Dots.ACS applied materials & interfaces · 2022Review
- Activation of retinal ganglion cells using a biomimetic artificial retina.Journal of neural engineering · 2021Article
- Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates.Communications biology · 2021Article
- Colour-sensitive conjugated polymer inkjet-printed pixelated artificial retina model studied via a bio-hybrid photovoltaic device.Scientific reports · 2020Article
- Characterization of an Electronic Corneal Prosthesis System.Current eye research · 2020Article
- Reconnecting Eye to Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Developing an Outcome Measure With High Luminance for Optogenetics Treatment of Severe Retinal Degenerations and for Gene Therapy of Cone Diseases.Investigative ophthalmology & visual science · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Optogenetics methods are rapidly being developed as therapeutic tools for treating neurological diseases, in particular, retinal degenerative diseases. A critical component of the development is testing the safety of the light stimulation used to activate the optogenetic proteins. While the stimulation needs to be sufficient to produce neural responses in the targeted retinal cell class, it also needs to be below photochemical and photothermal limits known to cause ocular damage. The maximal permissible exposure is determined by a variety of factors, including wavelength, exposure duration, visual angle, pupil size, pulse width, pulse pattern, and repetition frequency. In this paper, we develop utilities to systematically and efficiently assess the contributions of these parameters in relation to the limits, following directly from the 2014 American National Standards Institute (ANSI). We also provide an array of stimulus protocols that fall within the bounds of both safety and effectiveness. Additional verification of safety is provided with a case study in rats using one of these protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.