Evidence map›Paper›PMID 26882922›Full record

Trial reportJournal of anesthesia2016

Comparison of the analgesic effect of intravenous acetaminophen with that of flurbiprofen axetil on post-breast surgery pain: a randomized controlled trial.

Takahiro Nonaka, Marie Hara, Chisato Miyamoto, Michiko Sugita, Tatsuo Yamamoto

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of anesthesia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05757388 (The Efficacy of Intraoperative Parecoxib Combined With Paracetamol for Reducing Opioid Consumption in Patients Undergoing Breast Cancer Surgery Under General Anesthesia), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05757388 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Efficacy of Intraoperative Parecoxib Combined With Paracetamol for Reducing Opioid Consumption in Patients Undergoing Breast Cancer Surgery Under General Anesthesia: A Prospective Randomized Controlled Trial

TypeinterventionalSponsorKhon Kaen UniversityRan2023 to 2023Enrolled60ConditionsPost Operative PainArmsParecoxib + paracetamol, Normal saline
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. NSAIDs in the Treatment of Postoperative Pain.Current pain and headache reports · 2016
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Takahiro NonakaDepartment of Anesthesiology, Kumamoto University Hospital, Kumamoto, Japan.
Marie HaraDepartment of Anesthesiology, Kumamoto University Hospital, Kumamoto, Japan.
Chisato MiyamotoDepartment of Anesthesiology, Kumamoto University Hospital, Kumamoto, Japan.
Michiko SugitaDepartment of Anesthesiology, Kumamoto University Hospital, Kumamoto, Japan.
Tatsuo YamamotoDepartment of Anesthesiology, Kumamoto University Hospital, Kumamoto, Japan. yamamotot@fc.kuh.kumamoto-u.ac.jp.
Kumamoto University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAcetaminophen is known to be a relatively weak analgesic with fewer side effects than nonsteroidal anti-inflammatory drugs (NSAIDs). This study aimed to determine whether intravenous (iv) acetaminophen produces comparable analgesic effects to those of flurbiprofen (positive control drug), an intravenously injectable NSAID, after partial mastectomies. The primary outcome assessed was pain intensity during the first 24 h after the operation, and the secondary outcome was the satisfaction rating at discharge.

methodsAfter obtaining Institutional Ethics Committee approval, a series of 40 consecutive female patients who were scheduled for partial mastectomies were enrolled. Participants were randomly divided into two groups: an acetaminophen (1000 mg × 3) group (group A) and a flurbiprofen (50 mg × 3) group (group F). Each drug was administered 15 min before the end of surgery, and at 6 and 12 h after the operation. Postoperative pain was evaluated using a 100-mm visual analog scale (VAS) at 3, 6, and 24 h postoperatively. Satisfaction rating was evaluated on a 5-point scale (very good, good, well, bad, and very bad).

resultsVAS scores (mm) with movement in groups A and F at 3, 6, and 24 h after the surgery were 22 vs. 28, 14 vs. 24, and 12 vs. 20.5 (median), respectively, with no significant differences between the two groups. Eighteen of 20 patients in group A and 20 of 20 patients in group F expressed a satisfaction rating of greater than good.

conclusionsAcetaminophen produces an equivalent analgesic effect to flurbiprofen in post-partial mastectomy patients.

Indexed as

AcetaminophenAdultAgedAnalgesics, Non-NarcoticAnti-Inflammatory Agents, Non-SteroidalBreastDouble-Blind MethodFemaleFlurbiprofenHumansMastectomyMiddle AgedPain MeasurementPatient SatisfactionPostoperative PainAcetaminophenAnalgesics, Non-NarcoticAnti-Inflammatory Agents, Non-SteroidalFlurbiprofenflurbiprofen axetilAcetaminophenNSAIDsPostoperative pain

Identifiers

PMID26882922
OpenAlexW2281139874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.