Evidence map›Paper›PMID 26882910›Full record

Trial reportCirculation2016

Swimming-Induced Pulmonary Edema: Pathophysiology and Risk Reduction With Sildenafil.

Richard E Moon, Stefanie D Martina, Dionne F Peacher, Jennifer F Potter, Tracy E Wester, Anne D Cherry, Michael J Natoli, Claire E Otteni, Dawn N Kernagis, William D White and 1 more

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00815646 (Effects of the Dive Reflex on Pulmonary Arterial and Pulmonary Artery Wedge Pressures in Subjects Who Have Experienced Immersion Pulmonary Edema), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00815646 early_phase1completednot on this map

Effects of the Dive Reflex on Pulmonary Arterial and Pulmonary Artery Wedge Pressures in Subjects Who Have Experienced Immersion Pulmonary Edema

TypeinterventionalSponsorDuke UniversityRan2008 to 2015Enrolled10ConditionsImmersion Pulmonary Edema (IPE), Swimming Induced Pulmonary Edema (SIPE)ArmsSildenafil
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Oxygen uptake (Frontiers in physiology · 2023
    Article
  15. Swimming-induced pulmonary edema with review of literature.Medical journal, Armed Forces India · 2022
    Article
  16. Article
  17. Article
  18. Observational
  19. Cardiovascular considerations for scuba divers.Heart (British Cardiac Society) · 2022
    Review
  20. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Richard E MoonFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.). richard.moon@duke.edu.
Stefanie D MartinaFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.).
Dionne F PeacherFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.).
Jennifer F PotterFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.).
Tracy E WesterFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.).
Anne D CherryFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.).
Michael J NatoliFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.).
Claire E OtteniFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.).
Dawn N KernagisFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.).
William D WhiteFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.).
John J FreibergerFrom Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.).
Duke University Hospital · USUniversity of Virginia · USMedical University of South Carolina · USUniversity of Pennsylvania · USDelaware County Memorial Hospital · US

Funding

INTEGRATED TRAINING IN ANESTHESIOLOGY RESEARCHT32GM008600 · NIGMS · DUKE UNIVERSITY · PI Miriam Treggiari · 1996 to 2026
$6.6M
ANIMAL HUSBANDRY SUPPORT SERVICES FOR NIEHS27304C0002 · NIEHS · 2007 to 2008
$5.0M
Role of Mitochondrial CYP2E1 in Chemical Exposure-Driven NeurodegenerationF32ES027306 · NIEHS · DUKE UNIVERSITY · PI HARTMAN, JESSICA HELENE · 2016 to 2018
$171k
Investigation of metabolites related to manganese exposureF31ES027304 · NIEHS · UNIVERSITY OF WASHINGTON · PI BAKER, MARISSA GAYL · 2016 to 2017
$61k
NIEHS NIH HHS 27304C0002NIEHS NIH HHS 27306C0002NIGMS NIH HHS T32 GM008600
6 · The paper itself

Abstract

backgroundSwimming-induced pulmonary edema (SIPE) occurs during swimming or scuba diving, often in young individuals with no predisposing conditions, and its pathophysiology is poorly understood. This study tested the hypothesis that pulmonary artery and pulmonary artery wedge pressures are higher in SIPE-susceptible individuals during submerged exercise than in the general population and are reduced by sildenafil. METHODS AND

resultsTen study subjects with a history of SIPE (mean age, 41.6 years) and 20 control subjects (mean age, 36.2 years) were instrumented with radial artery and pulmonary artery catheters and performed moderate cycle ergometer exercise for 6 to 7 minutes while submersed in 20°C water. SIPE-susceptible subjects repeated the exercise 150 minutes after oral administration of 50 mg sildenafil. Work rate and mean arterial pressure during exercise were similar in controls and SIPE-susceptible subjects. Average o2 and cardiac output in controls and SIPE-susceptible subjects were: o2 2.42 L·min(-1) versus 1.95 L·min(-1), P=0.2; and cardiac output 17.9 L·min(-1) versus 13.8 L·min(-1), P=0.01. Accounting for differences in cardiac output between groups, mean pulmonary artery pressure at cardiac output=13.8 L·min(-1) was 22.5 mm Hg in controls versus 34.0 mm Hg in SIPE-susceptible subjects (P=0.004), and the corresponding pulmonary artery wedge pressure was 11.0 mm Hg versus 18.8 mm Hg (P=0.028). After sildenafil, there were no statistically significant differences in mean pulmonary artery pressure or pulmonary artery wedge pressure between SIPE-susceptible subjects and controls.

conclusionsThese observations confirm that SIPE is a form of hemodynamic pulmonary edema. The reduction in pulmonary vascular pressures after sildenafil with no adverse effect on exercise hemodynamics suggests that it may be useful in SIPE prevention. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00815646.

Indexed as

Risk Reduction BehaviorAdultCardiac OutputCold TemperatureExercise TestFemaleHumansMaleMiddle AgedOxygen ConsumptionPulmonary EdemaPulmonary Wedge PressureSildenafil CitrateSwimmingVasodilator AgentsSildenafil CitrateVasodilator Agentsdivinghemodynamicsimmersionpulmonary circulationpulmonary edemaswimming

Identifiers

PMID26882910
PMCPMC5127690
OpenAlexW2285720266

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.