Evidence map›Paper›PMID 26882539›Full record

ArticleScientific data2016

An open access pilot freely sharing cancer genomic data from participants in Texas.

Lauren B Becnel, Stacey Pereira, Jennifer A Drummond, Marie-Claude Gingras, Kyle R Covington, Christie L Kovar, Harsha Vardhan Doddapaneni, Jianhong Hu, Donna Muzny, Amy L McGuire and 2 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. From DNA to Big Data: NGS Technologies and Their Applications.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. More options = more access.Nature medicine · 2016
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lauren B BecnelDan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Stacey PereiraCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas 77030, USA.
Jennifer A DrummondHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Marie-Claude GingrasHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Kyle R CovingtonHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Christie L KovarHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Harsha Vardhan DoddapaneniHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Jianhong HuHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Donna MuznyHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Amy L McGuireCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas 77030, USA.
David A WheelerHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.

Funding

The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3M
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
NCI NIH HHS P30 CA125123NHGRI NIH HHS U54 HG003273
6 · The paper itself

Abstract

Genomic data sharing in cancer has been restricted to aggregate or controlled-access initiatives to protect the privacy of research participants. By limiting access to these data, it has been argued that the autonomy of individuals who decide to participate in data sharing efforts has been superseded and the utility of the data as research and educational tools reduced. In a pilot Open Access (OA) project from the CPRIT-funded Texas Cancer Research Biobank, many Texas cancer patients were willing to openly share genomic data from tumor and normal matched pair specimens. For the first time, genetic data from 7 human cancer cases with matched normal are freely available without requirement for data use agreements nor any major restriction except that end users cannot attempt to re-identify the participants (http://txcrb.org/open.html).

Indexed as

Databases, GeneticDNA, NeoplasmGenome, HumanAccess to InformationBiological Specimen BanksHumansInformation DisseminationPancreatic NeoplasmsTexasDNA, Neoplasm

Identifiers

PMID26882539
PMCPMC4755126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.