ArticlePloS one2016
Phe362Tyr in AChE: A Major Factor Responsible for Azamethiphos Resistance in Lepeophtheirus salmonis in Norway.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Modelling the Effectiveness of Gene-Edited Salmon at Sea Lice Control and the Use of Refugia to Mitigate Counter-Adaptation.Evolutionary applications · 2025Article
- Zoonotic Agents in Farmed Fish: A Systematic Review from the Interdisciplinary Perspective of the One Health Concept.Veterinary sciences · 2025Review
- A modeling study of the impact of treatment policies on the evolution of resistance in sea lice on salmon farms.PloS one · 2023Article
- Control of parasitic diseases in aquaculture.Parasitology · 2022Review
- Trypsin Genes Are Regulated through the miRNA Bantam and Associated with Drug Sensitivity in the Sea LouseNon-coding RNA · 2021Article
- The potential for cleaner fish-driven evolution in the salmon louseEcology and evolution · 2021Article
- Genome wide analysis reveals genetic divergence between Goldsinny wrasse populations.BMC genetics · 2020Article
- Article
- Candidate genes for monitoring hydrogen peroxide resistance in the salmon louse, Lepeophtheirus salmonis.Parasites & vectors · 2020Article
- Article
- Caligus rogercresseyi acetylcholinesterase types and variants: a potential marker for organophosphate resistance.Parasites & vectors · 2018Article
- The Phe362Tyr mutation conveying resistance to organophosphates occurs in high frequencies in salmon lice collected from wild salmon and trout.Scientific reports · 2017Article
- The mechanism (Phe362Tyr mutation) behind resistance in Lepeophtheirus salmonis pre-dates organophosphate use in salmon farming.Scientific reports · 2017Article
- Article
- Managing aquatic parasites for reduced drug resistance: lessons from the land.Journal of the Royal Society, Interface · 2016Article
- Surveillance of the Sensitivity towards Antiparasitic Bath-Treatments in the Salmon Louse (Lepeophtheirus salmonis).PloS one · 2016Article
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4 authors.
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Abstract
Organophosphates (OP) are one of the major treatments used against the salmon louse (Lepeophtherius salmonis) in Norwegian salmonid aquaculture. The use of OP since the late 1970s has resulted in widespread resistant parasites. Recently, we reported a single mutation (Phe362Tyr) in acetylcholinesterase (AChE) as the major mechanism behind resistance in salmon louse towards OP. The present study was carried out to validate this mechanism at the field level. A total of 6658 salmon louse samples were enrolled from 56 different fish farms across the Norwegian coast, from Vest Agder in the south to Finnmark in the north. All the samples were genotyped using a TaqMan probe assay for the Phe362Tyr mutation. A strong association was observed between areas with frequent use of the OP (azamethiphos) and the Phe362Tyr mutation. This was confirmed at 15 sites where results from independently conducted bioassays and genotyping of parasites correlated well. Furthermore, genotyping of surviving and moribund parasites from six bioassay experiments demonstrated a highly significant negative correlation between the frequency of resistance alleles and the probability of dying when exposed to azamethiphos in a bioassay. Based on these observations, we could strongly conclude that the Phe362Tyr mutation is a major factor responsible for OP resistance in salmon louse on Norwegian fish farms.
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