ArticleAnnals of the American Thoracic Society2016
Airway Mucin 2 Is Decreased in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization.
Article in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01976117 (E-nose Utility in the Diagnosis of Bacterial Infection in Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
E-nose Utility in the Diagnosis of Bacterial Infection in Chronic Obstructive Pulmonary Disease (COPD)
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
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- Airway mucus in infection.Frontiers in physiology · 2026Review
- Hederasaponin C ameliorates chronic obstructive pulmonary disease pathogenesis by targeting TLR4 to inhibit NF-κB/MAPK signaling pathways.Chinese medicine · 2025Article
- The multifaceted roles of mucins family in lung cancer: from prognostic biomarkers to promising targets.Frontiers in immunology · 2025Review
- Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.The Journal of clinical investigation · 2022Article
- Review
- A Systematic Review and Meta-Analysis of the Prevalence and Impact of Pulmonary Bacterial Colonisation in Stable State Chronic Obstructive Pulmonary Disease (COPD).Biomedicines · 2021Review
- Candidate gene prioritization for chronic obstructive pulmonary disease using expression information in protein-protein interaction networks.BMC pulmonary medicine · 2021Article
- Reduced airway levels of fatty-acid binding protein 4 in COPD: relationship with airway infection and disease severity.Respiratory research · 2020Article
- Vitamin C and BJournal of biomedical materials research. Part A · 2019Article
- Engineering mucus to study and influence the microbiome.Nature reviews. Materials · 2019Article
- Pneumonia in Patients with Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2018Review
- Sampling Strategies for Three-Dimensional Spatial Community Structures in IBD Microbiota Research.Frontiers in cellular and infection microbiology · 2017Review
- Bronchiectasis in the Last Five Years: New Developments.Journal of clinical medicine · 2016Review
- Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization.Annals of the American Thoracic Society · 2016Article
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Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
Abstract
rationaleMucins are essential for airway defense against bacteria. We hypothesized that abnormal secreted airway mucin levels would be associated with bacterial colonization in patients with severe chronic obstructive pulmonary disease (COPD) Objectives: To investigate the relationship between mucin levels and the presence of potentially pathogenic micro-organisms in the airways of stable patients with severe COPD Methods: Clinically stable patients with severe COPD were examined prospectively. All patients underwent a computerized tomography scan, lung function tests, induced sputum collection, and bronchoscopy with bronchoalveolar lavage (BAL) and protected specimen brush. Patients with bronchiectasis were excluded. Secreted mucins (MUC2, MUC5AC, and MUC5B) and inflammatory markers were assessed in BAL and sputum by ELISA. MEASUREMENTS AND MAIN
resultsWe enrolled 45 patients, with mean age (±SD) of 67 (±8) years and mean FEV1 of 41 (±10) % predicted. A total of 31% (n = 14) of patients had potentially pathogenic micro-organisms in quantitative bacterial cultures of samples obtained by protected specimen brush. Patients with COPD with positive cultures had lower levels of MUC2 both in BAL (P = 0.02) and in sputum (P = 0.01). No differences in MUC5B or MUC5AC levels were observed among the groups. Lower MUC2 levels were correlated with lower FEV1 (r = 0.32, P = 0.04) and higher sputum IL-6 (r = -0.40, P = 0.01).
conclusionsAirway MUC2 levels are decreased in patients with severe COPD colonized by potentially pathogenic micro-organisms. These findings may indicate one of the mechanisms underlying airway colonization in patients with severe COPD. Clinical trial registered with www.clinicaltrials.gov (NCT01976117).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.