ArticleThe ISME journal2016
The bacterial microbiome of Dermacentor andersoni ticks influences pathogen susceptibility.
Article in The ISME journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
136 citing papers in PubMed.
- Tick Microbiome and Its Role in Emerging Zoonotic Diseases and Transmissibility.Microorganisms · 2026Review
- High throughput sequencing in the diagnosis and surveillance of tick-borne diseases: A narrative review.One health (Amsterdam, Netherlands) · 2026Review
- Immune-mediated microbial interference governsiScience · 2026Article
- Characterization of bacterial microbiome and molecular detection of rickettsiosis in free-living ticks (Amblyomma sculptum Berlese, 1888).Scientific reports · 2026Article
- Transcriptome of Coxiella-like endosymbionts in Haemaphysalis longicornis during blood feeding.The Journal of veterinary medical science · 2026Article
- Interaction between tick and host microbiotas: a four-step waltz.Parasites & vectors · 2026Review
- Rhipicephalus sanguineus s.l. ticks (Acari: Ixodidae) harbor non-divergent bacterial microbiomes in Arizona.Journal of medical entomology · 2026Article
- Spatiotemporal and tissue-specific dynamics of bacterial communities in adult femaleFrontiers in cellular and infection microbiology · 2026Article
- Sexual and regional differences in the microbiome and functional metagenome of the lone star tick, Amblyomma americanum.Animal microbiome · 2025Article
- Genome-resolved metagenomics reveals microbiome diversity across 48 tick species.Nature microbiology · 2025Article
- The differences in microbial communities and Tick-Borne pathogens between Dermacentor marginatus and Hyalomma asiaticum collected from the Northwestern Xinjiang Uygur Autonomous Region, China.BMC infectious diseases · 2025Article
- Behavioral manipulation ofmBio · 2025Article
- Tick-Borne Viruses in a Changing Climate: The Expanding Threat in Africa and Beyond.Microorganisms · 2025Review
- Alterations in the salivary gland microbiota ofZoological research · 2025Article
- Potential mechanisms implied in tick infection by arboviruses and their transmission to vertebrate hosts.Integrative zoology · 2025Review
- A review of filarial nematodes parasitizing tick vectors: unraveling global patterns in species diversity, host associations, and interactions with tick-borne pathogens.Parasites & vectors · 2025Review
- Article
- Bacterial blood microbiome ofFrontiers in cellular and infection microbiology · 2025Article
- Differential impact of spotted fever groupFrontiers in microbiology · 2025Article
- Microbiome ofInsects · 2024Article
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Ticks are of medical importance owing to their ability to transmit pathogens to humans and animals. The Rocky Mountain wood tick, Dermacentor andersoni, is a vector of a number of pathogens, including Anaplasma marginale, which is the most widespread tick-borne pathogen of livestock. Although ticks host pathogenic bacteria, they also harbor bacterial endosymbionts that have a role in tick physiology, survival, as well as pathogen acquisition and transmission. The goal of this study was to characterize the bacterial microbiome and examine the impact of microbiome disruption on pathogen susceptibility. The bacterial microbiome of two populations of D. andersoni with historically different susceptibilities to A. marginale was characterized. In this study, the microbiome was disrupted and then ticks were exposed to A. marginale or Francisella novicida to determine whether the microbiome correlated with pathogen susceptibility. Our study showed that an increase in proportion and quantity of Rickettsia bellii in the microbiome was negatively correlated to A. marginale levels in ticks. Furthermore, a decrease in Francisella endosymbionts was associated with lower F. novicida infection levels, demonstrating a positive pathogen-endosymbiont relationship. We demonstrate that endosymbionts and pathogens have varying interactions, and suggest that microbiome manipulation may provide a possible method for biocontrol by decreasing pathogen susceptibility of ticks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.